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The detection of parabens in the placenta or amniotic fluid raised concerns about potential health consequences for the child. Recently, an increased asthma risk following prenatal exposure has been reported. Here, we investigated whether prenatal paraben exposure can influence the risk for atopic dermatitis (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>261 mother\u2010child pairs of the German mother\u2010child study LINA were included in this analysis. Eight paraben species were quantified in maternal urine obtained at gestational week 34. According to the parental report of physician\u2010diagnosed AD from age 1 to 8\u00a0years, disease onset, and persistence, childhood AD was classified into four different phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>4.6% (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) and 12.3% (<jats:italic>n<\/jats:italic>\u00a0=\u00a032) of the children were classified as having very early\u2010onset AD (until age two) either with or without remission, 11.9% (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) as early\u2010onset (after age two), and 3.1% (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) as childhood\u2010onset AD (after age six). Exposure to ethylparaben and <jats:italic>n<\/jats:italic>\u2010butylparaben was associated with an increased risk to develop very early\u2010onset AD without remission (EtP: adj.OR\/95% CI:1.44\/1.04\u20132.00,nBuP:adj.OR\/95% CI:1.95\/1.22\u20133.12). The effects of both parabens were predominant in children without a history of maternal AD and independent of children's sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prenatal EtP or nBuP exposure may increase children's susceptibility for persistent AD with disease onset at very early age. This association was particularly pronounced in children without a history of maternal AD, indicating that children without a genetic predisposition are more susceptible to paraben exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14890","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T08:46:26Z","timestamp":1619945186000},"page":"3122-3132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Prenatal paraben exposure and atopic dermatitis\u2010related outcomes among children"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1109-1924","authenticated-orcid":false,"given":"Loreen","family":"Th\u00fcrmann","sequence":"first","affiliation":[{"name":"Molecular Epidemiology Unit Berlin Institute of Health at Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu 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