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Endotyping is gaining favour over phenotype\u2010based classifications, owing to its potential in prognosticating disease severity and delivering precision treatment. Endotyping is especially useful in challenging CRS with nasal polyposis cases, for whom novel treatment options such as biologicals are now available. The latest European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS2020) reflects these changes with updated rhinosinusitis classifications and new integrated care pathways. With the coronavirus disease 2019 (COVID\u201019) pandemic, physicians and rhinologists have to balance the responsibility of managing their patients\u2019 upper airway while adequately protecting themselves from droplet and aerosol transmission. This review summarises the key updates from EPOS2020, endotype\u2010based classification and biomarkers. The role of biologicals in CRS and the lessons we can draw from their use in severe asthma will be examined. Finally, the principles of CRS management during COVID\u201019 will also be discussed.<\/jats:p>","DOI":"10.1111\/all.14892","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T22:01:37Z","timestamp":1620165697000},"page":"3349-3358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Highlights in the advances of chronic rhinosinusitis"],"prefix":"10.1111","volume":"76","author":[{"given":"Xinni","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head &amp; Neck Surgery National University Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sietze","family":"Reitsma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Amsterdam University Medical Centers, location AMC Amsterdam The 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