{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:15:36Z","timestamp":1790730936026,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013995","name":"Sanofi Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The human monoclonal antibody dupilumab blocks interleukin (IL)\u20104 andIL\u201013, key and central drivers of type 2 inflammation. Dupilumab, on background mometasone furoate nasal spray (MFNS), improved outcomes in the phase III SINUS\u201052 study (NCT02898454) in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP). This posthoc analysis of SINUS\u201052 examined whether eosinophilic status of CRSwNP was a predictor of dupilumab efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients were randomized 1:1:1 to dupilumab 300\u00a0mg every 2\u00a0weeks (q2w) until week 52; dupilumab 300\u00a0mg q2w until Week 24, then 300\u00a0mg every 4\u00a0weeks until week 52; or placebo (MFNS) until week 52. Coprimary endpoints were change from baseline in nasal polyps score (NPS), nasal congestion (NC), and Lund\u2010Mackay score assessed by CT (LMK\u2010CT) at week 24. Patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0438) were stratified by eosinophilic chronic rhinosinusitis (ECRS) status according to the Japanese Epidemiological Survey of Refractory Eosinophilic Rhinosinusitis algorithm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dupilumab significantly improved NPS, NC, and LMK\u2010CT scores versus placebo at week 24 in all ECRS subgroups\n                      <jats:italic>(p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), with improvements maintained or increased at week 52\n                      <jats:italic>(p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). There was no significant interaction between ECRS subgroup (non\u2010\/mild or moderate\/severe) and dupilumab treatment effect for all endpoints at weeks 24 and 52\n                      <jats:italic>(p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05), except LMK\u2010CT at week 24\n                      <jats:italic>(p<\/jats:italic>\n                      \u00a0=\u00a00.0275). Similar results were seen for the secondary endpoints. Dupilumab was well tolerated across all ECRS subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dupilumab produced consistent improvement in symptoms of severe CRSwNP irrespective of ECRS status. Therefore, blood eosinophil level may not be a suitable biomarker for dupilumab efficacy in CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14906","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T03:02:40Z","timestamp":1621134160000},"page":"186-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS\u201052 is unaffected by eosinophilic status"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-7377","authenticated-orcid":false,"given":"Shigeharu","family":"Fujieda","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Matsune","sequence":"additional","affiliation":[{"name":"Nippon Medical School Musashi Kosugi Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachio","family":"Takeno","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Tohoku Medical and Pharmaceutical University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiya","family":"Asako","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kansai Medical University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-1665","authenticated-orcid":false,"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose, and Throat Science Ghent University Ghent Belgium"},{"name":"Department of Clinical Science, Intervention and Technology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Sanofi K.K. 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