{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:39:59Z","timestamp":1792427999327,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatments for alopecia areata (AA) patients with extensive scalp hair loss are limited, and recent evidence supports a role for type 2 T\u2010cell (Th2)\u2010immune response in AA. Dupilumab, a monoclonal antibody inhibiting Th2 signaling, approved for type 2 diseases including atopic dermatitis, was evaluated in AA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Alopecia areata patients with and without concomitant atopic dermatitis were randomized 2:1 to receive weekly subcutaneous dupilumab (300\u00a0mg) or placebo for 24\u00a0weeks, followed by another 24\u2010week dupilumab open\u2010label phase. The primary outcome was change from baseline in the Severity of Alopecia Tool (SALT) score at week 24; secondary outcomes included a range of measures of hair regrowth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty and 20 patients were assigned to the dupilumab and placebo arms, respectively. At week 24, disease worsening was documented in the placebo arm, with a least\u2010squares mean change in the SALT score of \u22126.5 (95% confidence\u2010interval [CI], \u221210.4 to \u22122.6), versus a change of 2.2 (95% CI, \u22120.6 to 4.94) in the dupilumab arm (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). After 48\u00a0weeks of dupilumab treatment, 32.5%, 22.5% and 15% of patients achieved SALT\n                      <jats:sub>30<\/jats:sub>\n                      \/SALT\n                      <jats:sub>50<\/jats:sub>\n                      \/SALT\n                      <jats:sub>75<\/jats:sub>\n                      improvement, respectively, while in patients with baseline IgE\u00a0\u2265\u00a0200\u00a0IU\/ml response rates increased to 53.8%, 46.2%, and 38.5%, respectively. Moreover, baseline IgE predicts treatment response with 83% accuracy. No new safety signals were detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This hypothesis\u2010driven trial is the first to indicate the possible pathogenic role of the Th2 axis and Th2 targeting in AA patients. Patient selection based on baseline serum IgE levels may improve treatment results (Clinicaltrials.gov number, NCT03359356).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.15071","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T13:27:26Z","timestamp":1630330046000},"page":"897-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":151,"title":["Phase 2a randomized clinical trial of dupilumab (anti\u2010IL\u20104R\u03b1) for alopecia areata patients"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-324X","authenticated-orcid":false,"given":"Emma","family":"Guttman\u2010Yassky","sequence":"first","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai New York NY 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Dermatology UC Davis Medical Center University of California Davis Health System Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Gilleaudeau","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology Rockefeller University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Sullivan\u2010Whalen","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology Rockefeller University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle K.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Garcet","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology Rockefeller University New York NY 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