{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:13:23Z","timestamp":1793304803246,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Factors predicting allergic sensitization in the first 6\u00a0months of life are poorly understood. We aimed to determine whether eczema, dry skin, and high transepidermal water loss (TEWL) at 3\u00a0months were associated with allergic sensitization at 6\u00a0months of age and, secondarily, to establish whether these characteristics predicted sensitization from 3 to 6\u00a0months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At 3\u00a0months of age, 1,994 infants from the population\u2010based PreventADALL birth cohort in Norway and Sweden were assessed for eczema and dry skin on the cheeks and\/or extensors; impaired skin barrier function, defined as TEWL in the upper quartile (&gt;9.4\u00a0g\/m<jats:sup>2<\/jats:sup>\/h), and allergen\u2010specific IgE levels &lt;0.1\u00a0kU<jats:sub>A<\/jats:sub>\/L, available in 830. At 6\u00a0months, we assessed allergic sensitization to any food (egg, cow's milk, peanut, wheat, soy) or inhalant (birch, timothy grass, dog, and cat) allergen by a skin prick test wheal diameter \u22652\u00a0mm larger than negative control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Any sensitization was found in 198 of the 1,994 infants (9.9%), the majority to food allergens (<jats:italic>n<\/jats:italic>\u00a0=\u00a0177, 8.9%). Eczema, dry skin, and high TEWL at 3\u00a0months increased the risk of sensitization at 6\u00a0months; adjusted odds ratios 4.20 (95% CI 2.93\u20136.04), 2.09 (95% CI 1.51\u20132.90) and 3.67 (95% CI 2.58\u20135.22), respectively. Eczema predicted sensitization with 55.6% sensitivity and 68.1% specificity; dry skin with 65.3% sensitivity and 57.3% specificity; and high TEWL with 61.7% sensitivity and 78.1% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Eczema, dry skin, and high TEWL at 3\u00a0months predicted allergic sensitization at 6\u00a0months of age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15170","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T07:57:32Z","timestamp":1636099052000},"page":"1464-1476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Impaired skin barrier and allergic sensitization in early infancy"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1320-4021","authenticated-orcid":false,"given":"Sabina","family":"W\u00e4rnberg Gerdin","sequence":"first","affiliation":[{"name":"Astrid Lindgren Children\u2019s Hospital Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Women\u2019s and Children\u2019s Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anine","family":"Lie","sequence":"additional","affiliation":[{"name":"Division of Paediatric and Adolescent Medicine Oslo University Hospital  Oslo Norway"},{"name":"Faculty of Medicine Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Asarnoj","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children\u2019s Hospital Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Women\u2019s and Children\u2019s Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus P.","family":"Borres","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9257-1198","authenticated-orcid":false,"given":"Karin C.","family":"L\u00f8drup Carlsen","sequence":"additional","affiliation":[{"name":"Division of Paediatric and Adolescent Medicine Oslo University Hospital  Oslo Norway"},{"name":"Faculty of Medicine Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"F\u00e4rdig","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children\u2019s Hospital Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Women\u2019s and Children\u2019s Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7745-8624","authenticated-orcid":false,"given":"Jon R.","family":"Konradsen","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children\u2019s Hospital Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Women\u2019s and Children\u2019s Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Monceyron Jonassen","sequence":"additional","affiliation":[{"name":"Genetic Unit Centre for Laboratory Medicine \u00d8stfold Hospital Trust  Kalnes Norway"},{"name":"Faculty of Chemistry, Biotechnology and Food Science Norwegian University of Life Sciences  \u00c5s Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-9132","authenticated-orcid":false,"given":"Caroline\u2010Aleksi","family":"Olsson M\u00e4gi","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children\u2019s Hospital Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Women\u2019s and Children\u2019s Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Maria","family":"Rehbinder","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Dermatology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Rudi","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Biotechnology and Food Science Norwegian University of Life Sciences  \u00c5s Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0168-2616","authenticated-orcid":false,"given":"H\u00e5vard Ove","family":"Skjerven","sequence":"additional","affiliation":[{"name":"Division of Paediatric and Adolescent Medicine Oslo University Hospital  Oslo Norway"},{"name":"Faculty of Medicine Institute of Clinical Medicine University of 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