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Therefore, a bronchial allergen challenge (BAC) would be occasionally required to identify AA patients among atopic asthmatics. Nevertheless, BAC is usually considered a research tool only, with existing protocols being tailored to mild asthmatics and research needs (eg long washout period for inhaled corticosteroids). Consequently, existing BAC protocols are not designed to be performed in moderate\u2010to\u2010severe asthmatics or in clinical practice. The correct diagnosis of AA might help select patients for immunomodulatory therapies. Allergen sublingual immunotherapy is now registered and recommended for controlled or partially controlled patients with house dust mite\u2010driven AA and with FEV1\u00a0\u2265\u00a070%. Allergen avoidance is costly and difficult to implement for the management of AA, so the proper selection of patients is also beneficial. In this position paper, the EAACI Task Force proposes a methodology for clinical BAC that would need to be validated in future studies. The clinical implementation of BAC could ultimately translate into a better phenotyping of asthmatics in real life, and into a more accurate selection of patients for long\u2010term and costly management pathways.<\/jats:p>","DOI":"10.1111\/all.15203","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T07:19:58Z","timestamp":1641194398000},"page":"1667-1684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["EAACI position paper on the clinical use of the bronchial allergen challenge: Unmet needs and research priorities"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-364X","authenticated-orcid":false,"given":"Ioana","family":"Agache","sequence":"first","affiliation":[{"name":"Faculty of Medicine Transylvania University  Brasov Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Antolin\u2010Amerigo","sequence":"additional","affiliation":[{"name":"Servicio de Alergia Hospital Universitario Ram\u00f3n y Cajal Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5678-2214","authenticated-orcid":false,"given":"Frederic","family":"de Blay","sequence":"additional","affiliation":[{"name":"ALYATEC Environmental Exposure Chamber Chest Diseases Department Strasbourg University Hospital University of Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-8886","authenticated-orcid":false,"given":"Cristina","family":"Boccabella","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Universit\u00e0 Cattolica del Sacro Cuore Fondazione Policlinico Universitario A. 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