{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:42:57Z","timestamp":1793230977187,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pollen from grasses and trees can trigger allergic rhinitis (AR), where the symptoms and associated consequences can negatively affect quality of life (QoL). The Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) is frequently used in clinical trials of AR to assess QoL. To help interpret RQLQ data, the minimal important difference (MID) can be used to assess whether a mean difference in QoL between treatment groups is clinically meaningful. In seasonal allergy, an MID differs according to the allergen, pollen exposure, symptom severity, patient age and treatment; the same MID cannot be applied to all scenarios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from four Phase III clinical trials of SQ sublingual immunotherapy\u2010tablets in adults with moderate\u2010to\u2010severe allergy, between\u2010group MIDs were derived for the RQLQ in grass pollen allergy (during the peak [n\u00a0=\u00a0501] and entire [n\u00a0=\u00a0514] pollen seasons), and in tree pollen allergy (during the birch [n\u00a0=\u00a0516] and tree [n\u00a0=\u00a0518] pollen seasons), using anchor\u2010based methodology, supported by distribution\u2010based methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For grass pollen allergy, anchor\u2010based derived between\u2010group MIDs were 0.22 for the entire pollen season (n\u00a0=\u00a0343) and 0.10 for the peak pollen season (n\u00a0=\u00a0335). For tree pollen allergy, anchor\u2010based derived between\u2010group MIDs were 0.26 for the tree pollen season (n\u00a0=\u00a0306) and 0.16 for the birch pollen season (n\u00a0=\u00a0305) (representative of peak season). Distribution\u2010based derived MIDs were supportive of the anchor\u2010based values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis has derived between\u2010group MIDs specific to the trial populations evaluated and to the conditions under which the data were obtained, and highlights the need for a range of MIDs to reflect the unique nature of seasonal allergic disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15207","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:26:10Z","timestamp":1641428770000},"page":"1843-1851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Determining the minimal important differences in the RQLQ score with grass and tree allergy immunotherapy versus placebo in adults with moderate\u2010to\u2010severe allergy"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0733-9408","authenticated-orcid":false,"given":"Michael S.","family":"Blaiss","sequence":"first","affiliation":[{"name":"Medical College of Georgia at Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Gronskyte Juhl","sequence":"additional","affiliation":[{"name":"ALK\u2010Abell\u00f3 A\/S  H\u00f8rsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard Q.C.","family":"Siew","sequence":"additional","affiliation":[{"name":"Department of Adult Allergy Guy's and St Thomas' NHS Foundation Trust  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hammerby","sequence":"additional","affiliation":[{"name":"ALK\u2010Abell\u00f3 A\/S  H\u00f8rsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Devillier","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie Respiratoire \u2013 VIM Suresnes H\u00f4pital Foch, Suresnes Universit\u00e9 Paris Saclay  France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"European Academy of Allergy and Clinical Immunology (EAACI). Global atlas of allergic rhinitis and chronic rhinosinusitis. 2015."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10453-016-9459-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01393.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14111"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22073_c"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01583.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.047"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90005-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/78.11.1186"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.05.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.035"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.11.018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.12.1001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70135-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1586\/erp.11.12"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00044-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199915020-00003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.06.009"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12518"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.01.008"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0658-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-5751-12-10"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1991.tb00807.x"},{"key":"e_1_2_8_26_1","unstructured":"Measurement of Health\u2010Related Quality of Life and Asthma Control. Standardised rhinoconjunctivitis quality of life questionnaire (RQLQ[S]).https:\/\/www.qoltech.co.uk\/rqlq_s.html. Accessed December 23 2020."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-002-0464-0"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.07.011"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-016-0388-9"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083955"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-OA-0570"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.022"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(69)90018-5"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1988.tb02913.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90036-1"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4112"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990902774765"},{"issue":"3","key":"e_1_2_8_39_1","first-page":"225","article-title":"Comparison of powder and aerosolized budesonide in perennial rhinitis: validation of rhinitis quality of life questionnaire","volume":"70","author":"Juniper EF","year":"1993","journal-title":"Ann Allergy"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70380-5"},{"key":"e_1_2_8_41_1","first-page":"1","article-title":"An Introduction to the Bootstrap. Monographs on statistics and applied probability 57","author":"Efron B","year":"1993","journal-title":"Springer Science+Business Media Dordrecht"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.15207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.15207","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.15207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:53:55Z","timestamp":1692842035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.15207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,22]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/all.15207"],"URL":"https:\/\/doi.org\/10.1111\/all.15207","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,22]]},"assertion":[{"value":"2021-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}