{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:31:39Z","timestamp":1783467099490,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2\u2010mediated inflammatory disease with high symptom burden and reduced health\u2010related quality of life (HRQoL). This report aimed to comprehensively understand the effects of dupilumab on domains of HRQoL, their individual elements, and health status in patients with severe CRSwNP from phase 3 SINUS\u201024 (NCT02912468) and SINUS\u201052 (NCT02898454) trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomized to dupilumab (<jats:italic>n<\/jats:italic>\u00a0=\u00a0438) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a0286) for 24\u00a0weeks (SINUS\u201024), or 52\u00a0weeks (SINUS\u201052). Disease\u2010specific HRQoL using 22\u2010item sino\u2010nasal outcome test (SNOT\u201022), and health status using EuroQoL\u2010visual analog scale (EQ\u2010VAS) was evaluated in the pooled intention\u2010to\u2010treat (ITT) population (Week 24), SINUS\u201052 ITT (Week 52) and in the subgroups with\/without asthma; non\u2010steroidal anti\u2010inflammatory drug\u2010exacerbated respiratory disease (NSAID\u2010ERD); and prior sinus surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, patients had poor disease\u2010specific HRQoL and general health status and identified \u201cDecreased sense of smell\/taste\u201d and \u201cNasal blockage\u201d as the most important symptoms. Dupilumab significantly improved SNOT\u201022 total, domain (Nasal, Sleep, Function, Emotion, and Ear\/facial), and 22\u2010item scores, and EQ\u2010VAS, at Week 24 vs placebo (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), with continued improvements to Week 52 in SINUS\u201052. Improvements occurred irrespective of comorbid asthma, NSAID\u2010ERD, or prior surgery. A significantly greater proportion of dupilumab\u2010treated patients exceeded clinically meaningful thresholds for SNOT\u201022 total score and EQ\u2010VAS vs placebo (all subgroups <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05 except patients without surgery at Week 24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dupilumab treatment led to significant clinically meaningful improvements across all aspects of disease\u2010specific HRQoL, and general health status in patients with severe CRSwNP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15222","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T13:20:12Z","timestamp":1642339212000},"page":"2211-2221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Dupilumab improves health related quality of life: Results from the phase 3 SINUS studies"],"prefix":"10.1111","volume":"77","author":[{"given":"Stella E.","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2014Head &amp; Neck Surgery Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hopkins","sequence":"additional","affiliation":[{"name":"ENT Department Guy's and St Thomas' Hospitals King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic IDIBAPS Universitat de Barcelona CIBERES  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Msihid","sequence":"additional","affiliation":[{"name":"Sanofi  Chilly\u2010Mazarin 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