{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:12:19Z","timestamp":1787879539593,"version":"build-2784847793"},"reference-count":77,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anaphylaxis, which is rare, has been reported after COVID\u201019 vaccination, but its management is not standardized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre\u2010vaccination screening and management of allergic reactions to COVID\u201019 vaccines, and literature was analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No death due to anaphylaxis to COVID\u201019 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1\u2014anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2\u2014anaphylaxis to oral\/topical PEG containing products; 3\u2014recurrent anaphylaxis of unknown cause; 4\u2014suspected or confirmed allergy to any mRNA vaccine; and 5\u2014confirmed allergy to PEG or derivatives. We recommend a prick\u2010to\u2010prick skin test with the left\u2010over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID\u201019 vaccines and enable more people with history of allergy to be vaccinated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.15241","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T21:44:41Z","timestamp":1643838281000},"page":"2292-2312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Allergies and COVID\u201019 vaccines: An ENDA\/EAACI Position paper"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-1589","authenticated-orcid":false,"given":"Annick","family":"Barbaud","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique AP\u2010HP.Sorbonne Universit\u00e9, H\u00f4pital Tenon D\u00e9partement de dermatologie et allergologie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-4501","authenticated-orcid":false,"given":"Lene Heise","family":"Garvey","sequence":"additional","affiliation":[{"name":"Allergy Clinic Copenhagen University Hospital at Gentofte  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Arcolaci","sequence":"additional","affiliation":[{"name":"Immunology Unit University Hospital of Verona Policlinico G.B. 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