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The development of CRS is related to pathological mechanisms induced by hypoxia. Under hypoxic conditions, the stable expression of both Hypoxia inducible factor\u20101 (HIF\u20101) \u03b1 and HIF\u20102\u03b1 are involved in the immune response and inflammatory pathways of CRS. The imbalance in the composition of nasal microbiota may affect the hypoxic state of CRS and perpetuate existing inflammation. Hypoxia affects the differentiation of nasal epithelial cells such as ciliated cells and goblet cells, induces fibroblast proliferation, and leads to epithelial\u2010mesenchymal transition (EMT) and tissue remodeling. Hypoxia also affects the proliferation and differentiation of macrophages, eosinophils, basophils, and mast cells in sinonasal mucosa, and thus influences the inflammatory state of CRS by regulating T cells and B cells. Given the multifactorial nature in which HIF is linked to CRS, this study aims to elucidate the effect of hypoxia on the pathogenic mechanisms of CRS.<\/jats:p>","DOI":"10.1111\/all.15384","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T10:44:44Z","timestamp":1653302684000},"page":"3217-3232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The role of hypoxia in the pathophysiology of chronic rhinosinusitis"],"prefix":"10.1111","volume":"77","author":[{"given":"Bing","family":"Zhong","sequence":"first","affiliation":[{"name":"Upper Airways Research Laboratory, Department of Otolaryngology\u2010Head and Neck Surgery West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Otolaryngology, Infectious Diseases Translational Research Programme Yong Loo Lin School of Medicine National University of Singapore  Singapore 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