{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:44:35Z","timestamp":1771501475918,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic allergic reactions to vaccines are very rare. In this study we assessed the management and outcome of suspected SARS\u2010CoV\u20102 vaccine hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally, 334 individuals underwent an allergy work up regarding SARS\u2010CoV\u20102 vaccination (group A: 115 individuals suspected to be at increased risk for vaccine\u2010related reactions before vaccination and group B: 219 patients with reactions after COVID vaccination). The large majority of the SPT\/IDT with the vaccines were negative; however, we identified in 14.1% (<jats:italic>n<\/jats:italic>\u00a0=\u00a047) a possible sensitization to the SARS\u2010CoV\u20102 vaccine and\/or its ingredients defined as one positive skin test. Of the 219 individuals (group B) who experienced symptoms suspicious for a hypersensitivity reaction after vaccination, 214 were reported after the first vaccination with a mRNA vaccine (157 mRNA (Comirnaty\u00ae, 38 Spikevax\u00ae) and 18 with a vector vaccine (Vaxzevria\u00ae), 5 cases were after the second vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The symptom profile in group B was as follows: skin symptoms occurred in 115 cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a059 angioedema,<jats:italic>n<\/jats:italic>\u00a0=\u00a050 generalized urticaria and<jats:italic>n<\/jats:italic>\u00a0=\u00a023 erythema\/flush. Seventy individuals had cardiovascular, 53 respiratory and 17 gastrointestinal symptoms. Of the overall 334 individuals, 78 patients tolerated (re)\u2010vaccination (out of skin test positive\/negative 7\/19 from group A and 17\/35 from group B).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Proven IgE\u2010mediated hypersensitivity to SARS\u2010CoV\u20102 vaccines is extremely rare and not increased in comparison with reported hypersensitivity to other vaccines. The value of skin tests is unclear and nonspecific reactions, in particular when intradermal testing is applied, should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15414","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T08:38:54Z","timestamp":1655714334000},"page":"3426-3434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Management of suspected and confirmed<scp>COVID<\/scp>\u201019 (<scp>SARS\u2010CoV<\/scp>\u20102) vaccine hypersensitivity"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-1245","authenticated-orcid":false,"given":"Margitta","family":"Worm","sequence":"first","affiliation":[{"name":"Allergologie und Immunologie, Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Campus Charit\u00e9 Mitte, Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8674-5529","authenticated-orcid":false,"given":"Aikaterina","family":"Alexiou","sequence":"additional","affiliation":[{"name":"Allergologie und Immunologie, Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Campus Charit\u00e9 Mitte, Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bauer","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie, Comprehensive Allergy Center (CAC) Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-4742","authenticated-orcid":false,"given":"Regina","family":"Treudler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Venerologie und Allergologie, Leipziger Interdisziplin\u00e4res Centrum f\u00fcr Allergologie (CAC) Universit\u00e4tsmedizin Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerda","family":"Wurpts","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Allergologie, Aachener Comprehensive Allergy Center (ACAC) Universit\u00e4tsklinik der RWTH Aachen Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Dickel","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Allergologie, Berufs\u2010 und Umweltdermatologie, Klinik f\u00fcr Dermatologie, Venerologie und Allergologie St. Josef\u2010Hospital Ruhr\u2010Universit\u00e4t Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-129X","authenticated-orcid":false,"given":"Timo","family":"Buhl","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Universit\u00e4tsmedizin G\u00f6ttingen Georg\u2010August\u2010Universit\u00e4t G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert\u2010Ludwigs\u2010Universit\u00e4t Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Jung","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Universit\u00e4tsklinikum Gie\u00dfen Gie\u00dfen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randolf","family":"Brehler","sequence":"additional","affiliation":[{"name":"Ambulanz f\u00fcr Allergologie, Berufsdermatologie und Umweltmedizin Universit\u00e4tsklinikum M\u00fcnster M\u00fcnster 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