{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:04:01Z","timestamp":1792195441145,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is characterized by abnormal skin lipids that are largely driven by hyperactivated type 2 immune responses. The antibody to the \u03b1\u2010subunit of interleukin (IL)\u20104 receptor, dupilumab, was recently approved to treat AD and demonstrated strong efficacy. However, the role of dupilumab therapy in the regulation of skin barrier structure and function has not been fully explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We have evaluated the content of lipids and transepidermal water loss (TEWL) in lesional and non\u2010lesional skin of adults and adolescents with moderate\u2010to\u2010severe AD over the course of 16\u2010week treatment with dupilumab and compared those values with that of matched healthy volunteers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dupilumab treatment provided a significant decrease in TEWL in AD lesions, lowering it almost to the levels seen in the skin of healthy subjects. Blocking IL\u20104\/IL\u201013 signaling with dupilumab normalized lipid composition (decreased levels of ceramides with non\u2010hydroxy fatty acids and C18\u2010sphingosine and increased the level of esterified omega\u2010hydroxy fatty acid\u2010containing ceramides) and increased ceramide chain length in lesional as well as non\u2010lesional\n                      <jats:italic>stratum corneum<\/jats:italic>\n                      of AD patients. Partial changes for these parameters were already observed after 2\u2009weeks, with a full response achieved after 8\u2009weeks of dupilumab treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inhibition of IL\u20104\/IL\u201013 signaling by dupilumab allows restoration of skin lipid composition and barrier function in patients with moderate\u2010to\u2010severe AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.15432","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T08:04:35Z","timestamp":1657526675000},"page":"3388-3397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Dupilumab significantly improves skin barrier function in patients with moderate\u2010to\u2010severe atopic dermatitis"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1376-0098","authenticated-orcid":false,"given":"Evgeny","family":"Berdyshev","sequence":"first","affiliation":[{"name":"National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4685-9318","authenticated-orcid":false,"given":"Elena","family":"Goleva","sequence":"additional","affiliation":[{"name":"National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-6587","authenticated-orcid":false,"given":"Robert","family":"Bissonnette","sequence":"additional","affiliation":[{"name":"Innovaderm Research  Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-2496","authenticated-orcid":false,"given":"Irina","family":"Bronova","sequence":"additional","affiliation":[{"name":"National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9297-2082","authenticated-orcid":false,"given":"Anna Sofia","family":"Bronoff","sequence":"additional","affiliation":[{"name":"National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany N.","family":"Richers","sequence":"additional","affiliation":[{"name":"National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-245X","authenticated-orcid":false,"given":"Shannon","family":"Garcia","sequence":"additional","affiliation":[{"name":"National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4572-6115","authenticated-orcid":false,"given":"Marco","family":"Ramirez\u2010Gama","sequence":"additional","affiliation":[{"name":"National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6719-0449","authenticated-orcid":false,"given":"Patricia","family":"Taylor","sequence":"additional","affiliation":[{"name":"National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Praestgaard","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inoncent","family":"Agueusop","sequence":"additional","affiliation":[{"name":"Sanofi  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Jurvilliers","sequence":"additional","affiliation":[{"name":"Sanofi  Chilly\u2010Mazarin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1015-4439","authenticated-orcid":false,"given":"Mark","family":"Boguniewicz","sequence":"additional","affiliation":[{"name":"National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-5121","authenticated-orcid":false,"given":"Noah A.","family":"Levit","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc.  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