{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:16:08Z","timestamp":1790471768088,"version":"4.1.0"},"reference-count":155,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020\u2010114396RB\u2010I00"],"award-info":[{"award-number":["PID2020\u2010114396RB\u2010I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune diseases have a prevalence of approximately 7 to 9% and are classified as either organ\u2010specific diseases, including type I diabetes, multiple sclerosis, inflammatory bowel disease and myasthenia gravis, or systemic diseases, including systemic lupus erythematosus, rheumatoid arthritis and Sj\u00f6gren's syndrome. While many advancements have been made in understanding of the mechanisms of autoimmune disease, including the nature of self\u2010tolerance and its breakdown, there remain unmet needs in terms of effective and highly targeted treatments. T regulatory cells (Tregs) are key mediators of peripheral tolerance and are implicated in many autoimmune diseases, either as a result of reduced numbers or altered function. Tregs may be broadly divided into those generated in the thymus (tTregs) and those generated in the periphery (pTregs). Tregs target many different immune cell subsets and tissues to suppress excessive inflammation and to support tissue repair and homeostasis: there is a fine balance between Treg cell stability and the plasticity that is required to adjust Tregs' regulatory purposes to particular immune responses. The central role of immunoglobulin E (IgE) in allergic disease is well recognized, and it is becoming increasingly apparent that this immunoglobulin also has a wider role encompassing other diseases including autoimmune disease. Anti\u2010IgE treatment restores the capacity of plasmacytoid dendritic cells (pDCs) impaired by IgE\u2010 high\u2010affinity IgE receptor (Fc\u03b5R1) cross\u2010linking to induce Tregs in vitro in atopic patients. The finding that anti\u2010IgE therapy restores Treg cell homeostasis, and that this mechanism is associated with clinical improvement in asthma and chronic spontaneous urticaria suggests that anti\u2010IgE therapy may also have a potential role in the treatment of autoimmune diseases in which Tregs are involved.<\/jats:p>","DOI":"10.1111\/all.15449","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T15:22:15Z","timestamp":1658244135000},"page":"3293-3308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Regulatory T cells and immunoglobulin E: A new therapeutic link for autoimmunity?"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4516-0369","authenticated-orcid":false,"given":"Oscar","family":"Palomares","sequence":"first","affiliation":[{"name":"Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-974X","authenticated-orcid":false,"given":"Dirk","family":"Elewaut","sequence":"additional","affiliation":[{"name":"Department of Rheumatology VIB Center for Inflammation Research, Ghent University, Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0972-8148","authenticated-orcid":false,"given":"Peter M.","family":"Irving","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' Hospital Foundation Trust  London UK"},{"name":"King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4197-1634","authenticated-orcid":false,"given":"Xavier","family":"Jaumont","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-1795","authenticated-orcid":false,"given":"Paolo","family":"Tassinari","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25828-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3731"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00538-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14624"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0675-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2311-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13812"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12555"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14318"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14763"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15063"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0153-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006957"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0120-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750023598"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"85","article-title":"Serum IgE levels in patients with inflammatory bowel disease","volume":"56","author":"Levo Y","year":"1986","journal-title":"Ann Allergy"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-3-26"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2273"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12839"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2014.45"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00751-2020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.030"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.26"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0193"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.09.010"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0296-3"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13822"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2554"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.3.1151"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080939"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.693105"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00280.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8680-5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.600973"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15144"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802271"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1996.tb00906.x"},{"issue":"1","key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4049\/jimmunol.163.1.242","article-title":"Depletion of IL\u201010\u2010 and TGF\u2010\u03b2\u2010producing regulatory \u03b3\u03b4 T cells by administering a daunomycin\u2010conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells","volume":"163","author":"Seo N","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13011"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.04.070"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.10.002"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3646"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312717110"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.04.005"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110124"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3812"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.031"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.070"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.012"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02076-4"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16169"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.04.010"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/90667"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061660"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.031"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00455-x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15160"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.06.012"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14036"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02280"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090746"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.002"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1206095"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12396"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.051"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.032"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15193"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.1866"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9345-1"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1508749"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940045"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.156.6.1577"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.3.627"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3464"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.016"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.020"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02716"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001860"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi18-0058"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13346"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102761"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12561"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3900"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.09.012"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0892-8"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.03.019"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-008-0065-y"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319850"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.05.002"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14478"},{"key":"e_1_2_9_96_1","first-page":"10","article-title":"Past, present, and future of regulatory T cell therapy in transplantation and autoimmunity","volume":"31","author":"Romano M","year":"2019","journal-title":"Front Immunol"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.635767"},{"issue":"6","key":"e_1_2_9_98_1","first-page":"e581","article-title":"Immunomodulatory therapies for the treatment of graft\u2010versus\u2010host disease","volume":"5","author":"Braun LM","year":"2021","journal-title":"Hema"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.147474"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.654701"},{"key":"e_1_2_9_101_1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.4049\/jimmunol.102.4.884","article-title":"Histamine release from human leukocytes by anti\u2010gamma E antibodies","volume":"102","author":"Ishizaka T","year":"1969","journal-title":"J Immunol"},{"key":"e_1_2_9_102_1","first-page":"245","article-title":"The prevalence of IgE antinuclear antibodies in rheumatoid arthritis and systemic lupus erythematosus","volume":"86","author":"Permin H","year":"1978","journal-title":"Acta Pathol Microbiol Scand C"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1159\/000233200"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.5.2623"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/83784"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/83713"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/83707"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.046"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061328"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.10.026"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2021.03.003"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/antib5010002"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00689"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/antib9030047"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.050"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.09.016"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.03.016"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-015-0037-5"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13949"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090424"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.3357"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.622"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.4297"},{"issue":"7","key":"e_1_2_9_124_1","first-page":"646","article-title":"Case of primary Sj\u00f6gren's syndrome with hypereosinophilia and elevation of serum IgE: measurements of serum IL\u20104, IL\u20105 and the IgG subclass","volume":"54","author":"Azuma N","year":"2005","journal-title":"Arerugi"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.3.201"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020516029883"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0494-3"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9377-17"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2159"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3326"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5724"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.09.005"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39679"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1342"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-020-00442-0"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.047"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07674"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.04.090"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0472-4"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.01.011"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.032"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.08.066"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17229"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.033"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2021.11.e27"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13161"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40828"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1611778"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1976.tb04323.x"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00025-2"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.06.030"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00212"},{"issue":"4","key":"e_1_2_9_153_1","first-page":"1","article-title":"The effect of anti\u2010IgE therapy in knee osteoarthritis: a pilot observational study","volume":"31","author":"Aquili A","year":"2017","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.39905"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2246-4"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000537"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.15449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.15449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.15449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T19:19:30Z","timestamp":1692472770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.15449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":155,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/all.15449"],"URL":"https:\/\/doi.org\/10.1111\/all.15449","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,27]]},"assertion":[{"value":"2022-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}