{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:50:10Z","timestamp":1784825410082,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asthma, with several phenotypes and endotypes, is considered particularly suited for precision medicine. The identification of different non\u2010invasive biomarkers may facilitate diagnosis and treatment. Recently, Staphylococcus aureus and its enterotoxins (SE) have been found to have a role in inducing persistent type 2 airway inflammation in severe asthma, but also in such comorbidities as chronic rhinosinusitis with nasal polyposis (CRSwNP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The aim of this retrospective study was to evaluate the prevalence of SE\u2010IgE sensitization in a multicentric Italian cohort of severe asthmatic patients and correlate it with demographic and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 249 patients were included in the analysis, out of which 25.3% were staphylococcal enterotoxin B (SEB)\u2010IgE positive. We found a meaningful association between SEB\u2010IgE and female gender, a positive association was also measured between CRS and CRSwNP. No significant association was found between SEB\u2010IgE sensitization and atopy, the occurrence of exacerbations and corticosteroid dosages. In the SEB\u2010IgE\u2010positive patient, blood eosinophil count does not appear to be correlated with the severity of the disease. Patients with SEB\u2010IgE sensitization are, on average, younger and with an earlier disease onset, thus confirming the possibility to consider SEB\u2010IgE sensitization as an independent risk factor for developing asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data confirm that the search for SE in the initial screening phase of these patients is helpful to better phenotype them, may predict the evolution of comorbidities and lead to a targeted therapeutic choice; in this point of view this represents a goal of precision medicine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15466","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T01:39:00Z","timestamp":1659577140000},"page":"131-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Different aspects of severe asthma in real life: Role of <i>Staphylococcus aureus<\/i> enterotoxins and correlation to comorbidities and disease severity"],"prefix":"10.1111","volume":"78","author":[{"given":"Cristiano","family":"Caruso","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. 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Gemelli, IRCCS  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3661-5731","authenticated-orcid":false,"given":"Diego","family":"Bagnasco","sequence":"additional","affiliation":[{"name":"Allergy and Respiratory Diseases IRCCS Policlinico San Martino, University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5139-3604","authenticated-orcid":false,"given":"Giovanni","family":"Passalacqua","sequence":"additional","affiliation":[{"name":"Allergy and Respiratory Diseases IRCCS Policlinico San Martino, University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-1487","authenticated-orcid":false,"given":"Marco","family":"Caminati","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Verona and Verona University Hospital  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4718-5984","authenticated-orcid":false,"given":"Schiappoli","family":"Michele","sequence":"additional","affiliation":[{"name":"Asthma Center and Allergy Unit University of Verona and General Hospital  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianenrico","family":"Senna","sequence":"additional","affiliation":[{"name":"Asthma Center and Allergy Unit University of Verona and General Hospital  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0492-5663","authenticated-orcid":false,"given":"Enrico","family":"Heffler","sequence":"additional","affiliation":[{"name":"Personalized Medicine, Asthma and Allergy \u2010 Humanitas Clinical and Research Hospital IRCCS  Milan Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Walter","family":"Canonica","sequence":"additional","affiliation":[{"name":"Personalized Medicine, Asthma and Allergy \u2010 Humanitas Clinical and Research Hospital IRCCS  Milan Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"Crimi","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit A.O.U. \u201cPoliclinico\u2010Vittorio Emanuele\u201d  Catania Italy"},{"name":"Department of Clinical and Experimental Medicine, Section of Respiratory Medicine A.O.U. \u201cPoliclinico\u2010Vittorio Emanuele\u201d, University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Intravaia","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Section of Respiratory Medicine University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"De Corso","sequence":"additional","affiliation":[{"name":"Otolaryngology Institute\u2010Department of Head and Neck Fondazione Policlinico Universitario A. 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