{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:36:17Z","timestamp":1791725777735,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Protecting the skin barrier in early infancy may prevent atopic dermatitis (AD). We investigated if daily emollient use from birth to 2\u00a0months reduced AD incidence in high\u2010risk infants at 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center, two\u2010armed, investigator\u2010blinded, randomized controlled clinical trial (NCT03871998). Term infants identified as high risk for AD (parental history of AD, asthma or allergic rhinitis) were recruited within 4\u2009days of birth and randomised 1:1 to either twice\u2010daily emollient application for the first 8\u2009weeks of life (intervention group), using an emollient specifically formulated for very dry, AD\u2010prone skin, or to standard routine skin care (control group). The primary outcome was cumulative AD incidence at 12\u2009months. AD &lt;6\u00a0months was diagnosed based on clinical presence of AD. The UK Working Party Diagnostic Criteria were applied when diagnosing AD between 6 and 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred twenty\u2010one were randomised (161 intervention and 160 control), with 61 withdrawals (41 intervention, 20 control). The cumulative incidence of AD at 12\u2009months was 32.8% in the intervention group vs. 46.4% in the control group, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.036 [Relative risk (95%CI): 0.707 (0.516, 0.965)]. One infant in the intervention group was withdrawn from the study following development of a rash that had a potential relationship with the emollient. There was no significant difference in the incidence of skin infections between the intervention and control groups during the intervention period (5.0% vs. 5.7%, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study has demonstrated that early initiation of daily specialized emollient use until 2\u00a0months reduces the incidence of AD in the first year of life in high\u2010risk infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15491","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T13:44:18Z","timestamp":1661262258000},"page":"984-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Early initiation of short\u2010term emollient use for the prevention of atopic dermatitis in high\u2010risk infants\u2014The STOP\u2010AD randomised controlled trial"],"prefix":"10.1111","volume":"78","author":[{"given":"Carol","family":"N\u00ed Chaoimh","sequence":"first","affiliation":[{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Paediatrics and Child Health University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanis","family":"Lad","sequence":"additional","affiliation":[{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Paediatrics and Child Health University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Nico","sequence":"additional","affiliation":[{"name":"River D International B.V.  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerwin J.","family":"Puppels","sequence":"additional","affiliation":[{"name":"River D International B.V.  Rotterdam The Netherlands"},{"name":"Department of Dermatology, Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. F. Colin C.","family":"Wong","sequence":"additional","affiliation":[{"name":"A*STAR Skin Research Labs  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Common","sequence":"additional","affiliation":[{"name":"A*STAR Skin Research Labs  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre M.","family":"Murray","sequence":"additional","affiliation":[{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Paediatrics and Child Health University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-2044","authenticated-orcid":false,"given":"Alan D.","family":"Irvine","sequence":"additional","affiliation":[{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Clinical Medicine, Trinity College  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4997-9857","authenticated-orcid":false,"given":"Jonathan O\u2019Brien","family":"Hourihane","sequence":"additional","affiliation":[{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Paediatrics and Child Health University College Cork  Cork Ireland"},{"name":"Paediatrics and Child Health Royal College of Surgeons in Ireland  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370220"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-RAI-0564"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.10.008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4770"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.060"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32984-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32983-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501636"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13847"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15116"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15747"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-4-S1-O8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01258.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.10.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08532.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245677"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu157"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.01.022"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15786"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024594"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2010.00611.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.15491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.15491","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.15491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:20:30Z","timestamp":1692706830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.15491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/all.15491"],"URL":"https:\/\/doi.org\/10.1111\/all.15491","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,8]]},"assertion":[{"value":"2022-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}