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Neutrophils were long regarded as the foot soldiers of the immune system, solely destined to execute a set of effector functions against invading pathogens before undergoing apoptosis, the latter of which was ascribed to their short life span. This simplistic understanding of neutrophils has now been revised on the basis of insights gained from the use of mouse models and single\u2010cell high\u2010throughput techniques, revealing tissue\u2010 and context\u2010specific roles of neutrophils in guiding immune responses. These studies also demonstrated that neutrophil responses were controlled by sophisticated feedback mechanisms, including directed chemotaxis of neutrophils to tissue\u2010draining lymph nodes resulting in modulation of antimicrobial immunity and inflammation. Moreover, findings in mice and humans showed that neutrophil responses adapted to different deterministic cytokine signals, which controlled their migration and effector function as well as, notably, their biologic clock by affecting the kinetics of their aging. These mechanistic insights have important implications for health and disease in humans, particularly, in allergic diseases, such as atopic dermatitis and allergic asthma bronchiale, as well as in autoinflammatory and autoimmune diseases. Hence, our improved understanding of neutrophils sheds light on novel therapeutic avenues, focusing on molecularly defined biologic agents.<\/jats:p>","DOI":"10.1111\/all.15505","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T12:29:14Z","timestamp":1662467354000},"page":"3567-3583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Mechanisms regulating neutrophil responses in immunity, allergy, and autoimmunity"],"prefix":"10.1111","volume":"77","author":[{"given":"Alaz","family":"\u00d6zcan","sequence":"first","affiliation":[{"name":"Department of Immunology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8279-5545","authenticated-orcid":false,"given":"Onur","family":"Boyman","sequence":"additional","affiliation":[{"name":"Department of Immunology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"},{"name":"Faculty of Science University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.006"},{"key":"e_1_2_13_3_1","unstructured":"LeidingJW HollandSM.Chronic granulomatous disease.GeneReviews\u00ae. 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