{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:30:01Z","timestamp":1789039801823,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) associated with type 2 inflammation and non\u2010steroidal anti\u2010inflammatory drug (NSAID)\u2010exacerbated respiratory disease (N\u2010ERD) can be difficult to control with standard medical therapy and sinus surgery. In this group, biologicals are potentially promising treatment options. The phase III clinical trials for omalizumab, dupilumab, mepolizumab and benralizumab in CRSwNP have demonstrated favourable outcomes. Moving forward, direct comparisons among biologicals, refining patient selection criteria for specific biologicals, determining optimal treatment duration and monitoring long\u2010term outcomes are areas of emerging interest. This review summarizes the clinical evidence from the recent 2\u2009years on the role of biologicals in severe CRSwNP and N\u2010ERD, and proposes an approach towards decision\u2010making in their use.<\/jats:p>","DOI":"10.1111\/all.15507","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T12:28:36Z","timestamp":1662467316000},"page":"3593-3605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Updates in biologic therapy for chronic rhinosinusitis with nasal polyps and\n                    <scp>NSAID<\/scp>\n                    \u2010exacerbated respiratory disease"],"prefix":"10.1111","volume":"77","author":[{"given":"Xinni","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head &amp; Neck Surgery National University Hospital  Singapore 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