{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:13:03Z","timestamp":1788455583972,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011860","name":"Campaign Urging Research for Eosinophilic Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011600","name":"Cancer Biology Research Center, Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011600","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001698","name":"Israel Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001742","name":"United States-Israel Binational Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001742","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic esophagitis (EoE) is a chronic, food\u2010driven allergic disease, characterized by eosinophil\u2010rich inflammation in the esophagus. The histopathological and clinical features of EoE have been attributed to overproduction of the type 2 cytokines IL\u20104 and IL\u201013, which mediate profound alterations in the esophageal epithelium and neutralizing of their shared receptor component (IL\u20104R\u03b1) with a human antibody drug (dupilumab) demonstrates clinical efficacy. Yet, the relative contribution of IL\u20104 and IL\u201013 and whether the type II IL\u20104 receptor (comprised of the IL\u20104R\u03b1 chain in association with IL\u201013R\u03b11) mediates this effect has not been determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Experimental EoE was induced in WT,\n                      <jats:italic>Il13ra1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      <jats:italic>,<\/jats:italic>\n                      and\n                      <jats:italic>Krt14<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>Cre<\/jats:italic>\n                      <\/jats:sup>\n                      <jats:italic>\/Il13ra1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>fl\/fl<\/jats:italic>\n                      <\/jats:sup>\n                      mice by skin\u2010sensitized using 4\u2010ethoxymethylene\u20102\u2010phenyl\u20102\u2010oxazolin (OXA) followed by intraesophageal challenges. Esophageal histopathology was determined histologically. RNA was extracted and sequenced for transcriptome analysis and compared with human EoE RNAseq data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Induction of experimental EoE in mice lacking\n                      <jats:italic>Il13ra1<\/jats:italic>\n                      and in vivo IL\u201013 antibody\u2010based neutralization experiments blocked antigen\u2010induced esophageal epithelial and lamina propria thickening, basal cell proliferation, eosinophilia, and tissue remodeling. In vivo targeted deletion of\n                      <jats:italic>Il13ra1<\/jats:italic>\n                      in esophageal epithelial cells rendered mice protected from experimental EoE. Single\u2010cell RNA sequencing analysis of human EoE biopsies revealed predominant expression of IL\u201013R\u03b11 in epithelial cells and that EoE signature genes correlated with IL\u201013 expression compared with IL\u20104.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrate a definitive role for IL\u201013 signaling via IL\u201013R\u03b11 in EoE. These data provide mechanistic insights into the mode of action of current therapies in EoE and highlight the type II IL\u20104R as a future therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.15510","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T10:24:01Z","timestamp":1662546241000},"page":"464-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Epithelial cell\u2010expressed type\n                    <scp>II IL<\/scp>\n                    \u20104 receptor mediates eosinophilic esophagitis"],"prefix":"10.1111","volume":"78","author":[{"given":"Shmulik","family":"Avlas","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Shani","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Rhone","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Itan","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avishay","family":"Dolitzky","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbal","family":"Hazut","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Grisaru\u2010Tal","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaara","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Shoda","sequence":"additional","affiliation":[{"name":"Division of Allergy\/Immunology, Department of Pediatrics Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Ballaban","sequence":"additional","affiliation":[{"name":"Division of Allergy\/Immunology, Department of Pediatrics Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6530-0387","authenticated-orcid":false,"given":"Netali Morgenstern","family":"Ben\u2010Baruch","sequence":"additional","affiliation":[{"name":"Division of Allergy\/Immunology, Department of Pediatrics Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Rochman","sequence":"additional","affiliation":[{"name":"Division of Allergy\/Immunology, Department of Pediatrics Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Diesendruck","sequence":"additional","affiliation":[{"name":"The Shmunis School of Biomedicine and Cancer Research, The George S. 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