{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:53:21Z","timestamp":1791795201790,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effectiveness of emollients for preventing atopic dermatitis\/eczema is controversial. The Barrier Enhancement for Eczema Prevention trial evaluated the effects of daily emollients during the first year of life on atopic dermatitis and atopic conditions to age 5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>1394 term infants with a family history of atopic disease were randomized (1:1) to daily emollient plus standard skin\u2010care advice (693 emollient group) or standard skin\u2010care advice alone (701 controls). Long\u2010term follow\u2010up at ages 3, 4 and 5\u2009years was via parental questionnaires. Main outcomes were parental report of a clinical diagnosis of atopic dermatitis and food allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Parents reported more frequent moisturizer application in the emollient group through to 5\u2009years. A clinical diagnosis of atopic dermatitis between 12 and 60\u2009months was reported for 188\/608 (31%) in the emollient group and 178\/631 (28%) in the control group (adjusted relative risk 1.10, 95% confidence interval 0.93 to 1.30). Although more parents in the emollient group reported food reactions in the previous year at 3 and 4\u2009years, cumulative incidence of doctor\u2010diagnosed food allergy by 5\u2009years was similar between groups (92\/609 [15%] emollients and 87\/632 [14%] controls, adjusted relative risk 1.11, 95% confidence interval 0.84 to 1.45). Findings were similar for cumulative incidence of asthma and hay fever.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Daily emollient application during the first year of life does not prevent atopic dermatitis, food allergy, asthma or hay fever.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.15555","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T02:37:25Z","timestamp":1666233445000},"page":"995-1006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Emollients for prevention of atopic dermatitis: 5\u2010year findings from the\n                    <scp>BEEP<\/scp>\n                    randomized trial"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-6040","authenticated-orcid":false,"given":"Lucy E.","family":"Bradshaw","sequence":"first","affiliation":[{"name":"Nottingham Clinical Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-5356","authenticated-orcid":false,"given":"Laura A.","family":"Wyatt","sequence":"additional","affiliation":[{"name":"Nottingham Clinical Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-5251","authenticated-orcid":false,"given":"Sara J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Skin Research Group, School of Medicine University of Dundee  Dundee UK"},{"name":"Department of Dermatology Ninewells Hospital and Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-0602","authenticated-orcid":false,"given":"Rachel H.","family":"Haines","sequence":"additional","affiliation":[{"name":"Nottingham Clinical Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-1606","authenticated-orcid":false,"given":"Alan A.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Nottingham Clinical Trials Unit, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9272-2585","authenticated-orcid":false,"given":"Michael R.","family":"Perkin","sequence":"additional","affiliation":[{"name":"Population Health Research Institute St. George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6163-5822","authenticated-orcid":false,"given":"Sandra","family":"Lawton","sequence":"additional","affiliation":[{"name":"Rotherham NHS Foundation Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8098-9220","authenticated-orcid":false,"given":"Tracey H.","family":"Sach","sequence":"additional","affiliation":[{"name":"Health Economics Group, Norwich Medical School University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-7367","authenticated-orcid":false,"given":"Joanne R.","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Centre of Evidence Based Dermatology, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7954-8823","authenticated-orcid":false,"given":"Matthew J.","family":"Ridd","sequence":"additional","affiliation":[{"name":"Population Health Sciences University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-6286","authenticated-orcid":false,"given":"Carsten","family":"Flohr","sequence":"additional","affiliation":[{"name":"Unit for Population\u2010Based Dermatology Research St John's Institute of Dermatology, Guy's &amp; 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