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Databases were searched for studies published between 2012 and 2021, added to studies published up to 2012. In total, 110 studies were included in this update. Most studies were graded as moderate risk of bias. Pooled lifetime and point prevalence of self\u2010reported FA were 19.9% (95% CI 16.6\u201323.3) and 13.1% (95% CI 11.3\u201314.8), respectively. The point prevalence of sensitization based on specific IgE (slgE) was 16.6% (95% CI 12.3\u201320.8), skin prick test (SPT) 5.7% (95% CI 3.9\u20137.4), and positive food challenge 0.8% (95% CI 0.5\u20130.9). While lifetime prevalence of self\u2010reported FA and food challenge positivity only slightly changed, the point prevalence of self\u2010reported FA, sIgE and SPT positivity increased from previous estimates. This may reflect a real increase, increased awareness, increased number of foods assessed, or increased number of studies from countries with less data in the first review. Future studies require rigorous designs and implementation of standardized methodology in diagnosing FA, including use of double\u2010blinded placebo\u2010controlled food challenge to minimize potential biases.<\/jats:p>","DOI":"10.1111\/all.15560","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T04:51:52Z","timestamp":1666414312000},"page":"351-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":252,"title":["Frequency of food allergy in Europe: An updated systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"78","author":[{"given":"Giulia C. 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