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We aimed to study the longitudinal development of sensitization to peanut extract and storage protein allergen molecules and associations with asthma status, airway and systemic inflammation markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Swedish birth cohort BAMSE followed 4089 participants with questionnaires, clinical investigations and blood sampling between 0 and 24\u2009years. Information on (i) background factors at 2\u00a0months, (ii) peanut allergy symptoms and IgE data (ImmunoCAP) at 4, 8, 16, and 24\u2009years, and (iii) IgE to storage proteins, lung function data including exhaled nitric oxide (FENO) as well as systemic inflammatory markers at 24\u2009years of age were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of peanut extract sensitization, defined as IgE\u2009\u2265\u20090.35\u2009kU<jats:sub>A<\/jats:sub>\/L, was 5.4%, 8.0%, 7.5%, and 6.2% at 4, 8, 16, and 24\u2009years of age, respectively. Between 8 and 24\u2009years of age, (33\/1565) participants developed IgE\u2010ab to peanut extract (median 1,4, range 0.7\u20132.6\u00a0kU<jats:sub>A<\/jats:sub>\/L), and among those 85% were also sensitized to birch. Only six individuals developed sensitization to Ara h 2 (\u22650.1\u00a0kU<jats:sub>A<\/jats:sub>\/L) between 8 and 24\u2009years of age, of whom three had an IgE\u2010ab level between 0.1\u20130.12\u2009kU<jats:sub>A<\/jats:sub>\/L. Storage protein sensitization was associated with elevated FENO, blood eosinophils and type 2 inflammation\u2010related systemic proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sensitization to peanut extract after 4\u2009years of age is mainly induced by birch cross\u2010sensitization and IgE to Ara h 2 rarely emerges after eight years of age. Storage protein sensitization is associated with respiratory and systemic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15568","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T14:59:15Z","timestamp":1667228355000},"page":"488-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development of sensitization to peanut and storage proteins and relation to markers of airway and systemic inflammation: A 24\u2010year follow\u2010up"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0157-5407","authenticated-orcid":false,"given":"Sandra G.","family":"Tedner","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden"},{"name":"Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm 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