{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:45:56Z","timestamp":1778071556147,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T00:00:00Z","timestamp":1671235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but potentially life\u2010threatening cutaneous adverse reactions. There is still no consensus on adjuvant treatments, and little is known about their effects on systemic inflammation in SJS\/TEN. Our aim was to characterize the systemic and cutaneous immune profiles of SJS\/TEN patients and to investigate whether\/how intravenous immunoglobulins (IVIG), cyclosporine A (CSA), and best supportive care only (BSCO) affected the systemic immune signature and clinical outcome (6\u00a0week\u2010mortality, complications, hospitalization stay).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 16 patients with SJS\/TEN, treated with high\u2010dose IVIG (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), CSA (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) or BSCO (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). Serial serum samples were obtained prior\u2010, 5\u20137\u2009days, and 21\u2009days after treatment onset. Serum levels of inflammation\u2212\/immune response\u2010associated proteins were measured by high\u2010throughput proteomics assay (OLINK) and cytotoxic molecules by ELISA. RNA extracted from skin biopsies collected prior treatment was analyzed by Nanostring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum inflammatory profiles in SJS\/TEN patients were notably characterized by massive upregulation of type 1 immune response and proinflammatory markers. Surprisingly, there was limited overlap between cutaneous and serum immune profiles. Serial serological measurements of immune response markers showed very diverse dynamics between the different treatment groups. IVIG\u2010treated patients showed completely different dynamics and most significant proteomic changes in an early phase (Day 5\u20137). In all treatment groups, type 1\u2212\/inflammatory response markers were dampened at day 21. Clinically, there were no outcome differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates that BSCO, CSA, and IVIG have very diverse biological effects on the systemic inflammatory response in SJS\/TEN, which may not correlate with clinical outcome differences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15608","type":"journal-article","created":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T12:00:00Z","timestamp":1670155200000},"page":"1280-1291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intravenous immunoglobulins, cyclosporine, and best supportive care in epidermal necrolysis: Diverse effects on systemic inflammation"],"prefix":"10.1111","volume":"78","author":[{"given":"Veronika","family":"Schmidt","sequence":"first","affiliation":[{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education  Davos 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Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milad","family":"Ameri","sequence":"additional","affiliation":[{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education  Davos Switzerland"},{"name":"Faculty of Medicine University Zurich  Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reihane","family":"Ziadlou","sequence":"additional","affiliation":[{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education  Davos Switzerland"},{"name":"Faculty of Medicine University Zurich  Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Ingen\u2010Housz\u2010Oro","sequence":"additional","affiliation":[{"name":"Department of Dermatology AP\u2010HP, Henri Mondor 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