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Released from airway epithelial cells exposed to environmental triggers, the alarmins drive airway inflammation through the release of predominantly T2 cytokines from multiple effector cells. The upstream positioning of the alarmins is an attractive pharmacological target to block multiple T2 pathways important in asthma. Blocking the function of TSLP inhibits allergen\u2010induced responses including bronchoconstriction, airway hyperresponsiveness, and inflammation, and subsequent clinical trials of an anti\u2010TSLP monoclonal antibody, tezepelumab, in asthma patients demonstrated improvements in lung function, airway responsiveness, inflammation, and importantly, a reduction in the rate of exacerbations. Notably, these improvements were observed in patients with T2\u2010high and with T2\u2010low asthma. Clinical trials blocking IL\u201033 and its receptor ST2 have also shown improvements in lung function and exacerbation rates; however, the impact of blocking the IL\u201033\/ST2 axis in T2\u2010high versus T2\u2010low asthma is unclear. To date, there is no evidence that IL\u201025 blockade is beneficial in asthma. Despite the considerable overlap in the cellular functions of IL\u201025, IL\u201033, and TSLP, they appear to have distinct roles in the immunopathology of asthma.<\/jats:p>","DOI":"10.1111\/all.15609","type":"journal-article","created":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T11:54:15Z","timestamp":1670154855000},"page":"402-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":140,"title":["Sounding the alarmins\u2014The role of alarmin cytokines in asthma"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6187-2385","authenticated-orcid":false,"given":"Gail M.","family":"Gauvreau","sequence":"first","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Bergeron","sequence":"additional","affiliation":[{"name":"Centre for Lung Health, Vancouver General Hospital 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