{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:28:06Z","timestamp":1791646086625,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG2K0332"],"award-info":[{"award-number":["CMRPG2K0332"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001130","name":"Gerber Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK040561"],"award-info":[{"award-number":["P30 DK040561"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The microbiome associations of food protein\u2010induced enterocolitis syndrome (FPIES) are understudied. We sought to prospectively define the clinical features of FPIES in a birth cohort, and investigate for the evidence of gut dysbiosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified children diagnosed with FPIES in the Gastrointestinal Microbiome and Allergic Proctocolitis Study, a healthy infant cohort. Children were assessed and stools were collected at each well child visit. The clinical features of the children with FPIES were summarized. Stool microbiome was analyzed using 16S rRNA sequencing comparing children with and without FPIES.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 874 children followed up for 3\u2009years, 8 FPIES cases (4 male) were identified, yielding a cumulative incidence of 0.92%. The most common triggers were oat and rice (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03, each) followed by milk (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02). The children with FPIES were more likely to have family history of food allergy (50% vs. 15.9% among unaffected,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.03). The average age of disease presentation was 6\u00a0months old. During the first 6\u00a0months of life, stool from children with FPIES contained significantly less\n                      <jats:italic>Bifidobacterium adolescentis<\/jats:italic>\n                      , but more pathobionts, including\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      spp. (especially\n                      <jats:italic>Bacteroides fragilis<\/jats:italic>\n                      ),\n                      <jats:italic>Holdemania<\/jats:italic>\n                      spp.,\n                      <jats:italic>Lachnobacterium<\/jats:italic>\n                      spp., and\n                      <jats:italic>Acinetobacter lwoffii<\/jats:italic>\n                      . The short\u2010chain fatty acid (SCFA)\u2010producing\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      shunt was expressed significantly less in the stool from FPIES children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this cohort, the cumulative incidence over the 3\u2010year study period was 0.92%. During the first 6 months of life, children with FPIES had evidence of dysbiosis and SCFA production pathway was expressed less in their stool, which may play an important role in the pathogenesis of FPIES.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.15644","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T22:04:26Z","timestamp":1673561066000},"page":"1595-1604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Early infancy dysbiosis in food protein\u2010induced enterocolitis syndrome: A prospective cohort study"],"prefix":"10.1111","volume":"78","author":[{"given":"Kuan\u2010Wen","family":"Su","sequence":"first","affiliation":[{"name":"Department of Pediatrics Keelung Chang Gung Memorial Hospital  Keelung Taiwan"},{"name":"Department of Pediatrics Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Cetinbas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria M.","family":"Martin","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Food Allergy Center Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamini V.","family":"Virkud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine University of North Carolina  North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Seay","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Ndahayo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Rosow","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Elkort","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Pediatrics at Newton Wellesley, P.C.  Newton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brinda","family":"Gupta","sequence":"additional","affiliation":[{"name":"Pediatrics at Newton Wellesley, P.C.  Newton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Kramer","sequence":"additional","affiliation":[{"name":"Pediatrics at Newton Wellesley, P.C.  Newton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana","family":"Pronchick","sequence":"additional","affiliation":[{"name":"Pediatrics at Newton Wellesley, P.C.  Newton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Reuter","sequence":"additional","affiliation":[{"name":"Pediatrics at Newton Wellesley, P.C.  Newton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan I.","family":"Sadreyev","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Long","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Pediatrics New Taipei Municipal TuCheng Hospital  New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne G.","family":"Shreffler","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Food Allergy Center Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Division of Pediatric Allergy and Immunology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Food Allergy Center Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Pediatrics at Newton Wellesley, P.C.  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