{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:17:42Z","timestamp":1791908262289,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accumulating evidence suggests that the gut microbiome is associated with asthma. However, altered gut microbiome in adult asthma is not yet well established. We aimed to investigate the gut microbiome profiles of adult asthmatic patients with symptomatic eosinophilic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 16\u2009s rRNA gene metagenomic analysis of feces in the symptomatic eosinophilic asthma group (EA, <jats:italic>n<\/jats:italic>\u00a0=\u00a028) was compared with the healthy control (HC, <jats:italic>n<\/jats:italic>\u00a0=\u00a018) and the chronic cough control (CC, <jats:italic>n<\/jats:italic>\u00a0=\u00a013). A correlation analysis between individual taxa and clinical markers was performed within the EA group. Changes in the gut microbiome were examined in patients with significant symptom improvement in the EA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The relative abundances of Lachnospiraceae and Oscillospiraceae significantly decreased and Bacteroidetes increased in the EA group. Within EA group, Lachnospiraceae was negatively correlated with indicators of type 2 inflammation and lung function decline. Enterobacteriaceae and <jats:italic>Prevotella<\/jats:italic> was positively associated with type 2 inflammation and lung function decline, respectively. The abundance of predicted genes associated with amino acid metabolism and secondary bile acid biosynthesis was diminished in the EA group. These functional gene family alterations could be related to gut permeability, and the serum lipopolysaccharide concentration was actually high in the EA group. EA patients with symptom improvement after 1\u00a0month did not show a significant change in the gut microbiome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Symptomatic eosinophilic adult asthma patients showed altered the gut microbiome composition. Specifically, a decrease in commensal clostridia was observed, and a decrease in Lachnospiraceae was correlated with blood eosinophilia and lung function decline.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15691","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T14:44:45Z","timestamp":1677509085000},"page":"1909-1921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Adult asthma with symptomatic eosinophilic inflammation is accompanied by alteration in gut microbiome"],"prefix":"10.1111","volume":"78","author":[{"given":"Bon\u2010Hee","family":"Gu","sequence":"first","affiliation":[{"name":"Life and Industry Convergence Research Institute Pusan National University  Miryang\u2010si South 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Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Internal Medicine, School of Medicine, Kyungpook National University Kyungpook National University Chilgok Hospital  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Internal Medicine, School of Medicine, Kyungpook National University Kyungpook National University Chilgok Hospital  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu South 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