{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:34:04Z","timestamp":1792794844159,"version":"4.5.0"},"reference-count":77,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010385","name":"Christine K\u00fchne \u2013 Center for Allergy Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) has long been regarded as a primarily pediatric disease. However, there is growing evidence for a high rate of adult\u2010onset AD. We aimed to characterize factors associated with adult\u2010onset versus childhood\u2010onset AD and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed cross\u2010sectional data of the CK\u2010CARE\u2010ProRaD cohorts Bonn, Augsburg, Davos, Z\u00fcrich of 736 adult patients stratified by age of AD onset (childhood\u2010onset &lt;18\u2009years: 76.4% (subsets: 0 to 2; \u22652 to 6; \u22657 to 11; \u226512 to 18); adult\u2010onset \u226518\u2009years: 23.6% (subsets: \u226518 to 40; \u226541 to 60; \u226561) and 167 controls (91 atopic, 76 non\u2010atopic)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified active smoking to be associated with adult\u2010onset AD versus controls (adjusted Odds Ratio (aOR)\u2009=\u20095.54 [95% Confidence Interval: 1.06\u201329.01] vs. controls\n                      <jats:sup>non\u2010atopic<\/jats:sup>\n                      , aOR\u2009=\u20094.03 [1.20\u201313.45] vs. controls\n                      <jats:sup>atopic<\/jats:sup>\n                      ). Conjunctivitis showed a negative association versus controls\n                      <jats:sup>atopic<\/jats:sup>\n                      (aOR\u2009=\u20090.36 [0.14\u20130.91]). Food allergy (aOR\u2009=\u20092.93 [1.44\u20135.96]), maternal food allergy (aOR\u2009=\u20099.43 [1.10\u201380.95]), palmar hyperlinearity (aOR\u2009=\u20092.11 [1.05\u20134.25]), and academic background (aOR\u2009=\u20092.14 [1.00\u20134.54]) increased the odds of childhood\u2010onset AD versus controls\n                      <jats:sup>atopic<\/jats:sup>\n                      . Shared AD\u2010associated factors were maternal AD (4\u201034x), increased IgE (2\u201020x), atopic stigmata (2\u20103x) with varying effect sizes depending on AD onset and control group. Patients with adult\u2010compared to childhood\u2010onset had doubled odds of allergic rhinitis (aOR\u2009=\u20092.15 [1.12\u20134.13]), but reduced odds to feature multiple (3\u20134) atopic comorbidities (aOR\u2009=\u20090.34 [0.14\u20130.84]). Adult\u2010onset AD, particularly onset \u226561\u2009years, grouped mainly in clusters with low contributions of personal and familial atopy and high frequencies of physical inactivity, childhood\u2010onset AD, particularly infant\u2010onset, mainly in \u201chigh\u2010atopic\u201d\u2010clusters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The identified associated factors suggest partly varying endo\u2010 and exogeneous mechanisms underlying adult\u2010onset versus childhood\u2010onset AD. Our findings might contribute to better assessment of the individual risk to develop AD throughout life and encourage prevention by non\u2010smoking and physical activity as modifiable lifestyle factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.15721","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T05:53:16Z","timestamp":1679464396000},"page":"2181-2201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Atopic dermatitis: Correlation of distinct risk factors with age of onset in adulthood compared to childhood"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-1530","authenticated-orcid":false,"given":"Laura","family":"Maintz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Bonn  Bonn Germany"},{"name":"Christine K\u00fchne\u2010Center for Allergy Research and 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