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Laundry detergents have been reported to have epithelial barrier\u2010opening effects. However, whether laundry detergents directly induce airway inflammation and its mechanisms in vivo remain to be elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two commercial laundry detergents and two commonly used surfactants for cleaning and cosmetics (sodium lauryl sulfate and sodium dodecyl benzene sulfonate) were intranasally administered to mice. Lungs were analyzed using flow cytometry, histology, ELISA, and quantitative PCR. Human bronchial epithelial cells were stimulated with laundry detergents and analyzed using quantitative PCR and western blotting. Involvement of oxidative stress was assessed using an antioxidant. Dust samples from homes were analyzed to determine their detergent content by measuring their critical micelle concentration (CMC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The administered laundry detergents and surfactants\u2010induced eosinophilic airway inflammation accompanied by increased IL\u201033 expression and activation of group 2 innate lymphoid cells (ILC2s). Detergent\u2010induced eosinophilic airway inflammation was significantly attenuated in Rag2<jats:sup>\u2212\/\u2212<\/jats:sup>Il2rg<jats:sup>\u2212\/\u2212<\/jats:sup>, Il33<jats:sup>\u2212\/\u2212<\/jats:sup> mice, and also in wild\u2010type mice treated with NAC. Detergent\u2010induced IL\u201033 expression in airways was attenuated by NAC treatment, both in vivo and in vitro. CMCs were found in all of the tested dust extracts, and they differed significantly among the homes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The laundry detergents and surfactants\u2010induced eosinophilic airway inflammation in vivo through epithelial cell and ILC2 activation. They induced IL\u201033 expression in airway epithelial cells through oxidative stress. Furthermore, detergent residues were present in house dust and are presumably inhaled into the airway in daily life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15762","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T04:46:16Z","timestamp":1683780376000},"page":"1878-1892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Laundry detergents and surfactants\u2010induced eosinophilic airway inflammation by increasing <scp>IL<\/scp>\u201033 expression and activating <scp>ILC2s<\/scp>"],"prefix":"10.1111","volume":"78","author":[{"given":"Kyoko","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Faculty of Medical Sciences University of Fukui  Fukui 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