{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:25:47Z","timestamp":1792797947400,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with significant morbidity and reduced health\u2010related quality of life. Findings from clinical trials have demonstrated the effectiveness of dupilumab in CRSwNP, although real\u2010world evidence is still limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This Phase IV real\u2010life, observational, multicenter study assessed the effectiveness and safety of dupilumab in patients with severe uncontrolled CRSwNP (<jats:italic>n<\/jats:italic>\u2009=\u2009648) over the first year of treatment. We collected data at baseline and after 1, 3, 6, 9, and 12\u2009months of follow\u2010up. We focused on nasal polyps score (NPS), symptoms, and olfactory function. We stratified outcomes by comorbidities, previous surgery, and adherence to intranasal corticosteroids, and examined the success rates based on current guidelines, as well as potential predictors of response at each timepoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a significant decrease in NPS from a median value of 6 (IQR 5\u20136) at baseline to 1.0 (IQR 0.0\u20132.0) at 12\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and a significant decrease in Sino\u2010Nasal Outcomes Test\u201022 (SNOT\u201022) from a median score of 58 (IQR 49\u201370) at baseline to 11 (IQR 6\u201321;<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) at 12\u2009months. Sniffin' Sticks scores showed a significant increase over 12\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) compared to baseline. The results were unaffected by concomitant diseases, number of previous surgeries, and adherence to topical steroids, except for minor differences in rapidity of action. An excellent\u2010moderate response was observed in 96.9% of patients at 12\u2009months based on EPOS 2020 criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings from this large\u2010scale real\u2010life study support the effectiveness of dupilumab as an add\u2010on therapy in patients with severe uncontrolled CRSwNP in reducing polyp size and improving the quality of life, severity of symptoms, nasal congestion, and smell.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15772","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:45:55Z","timestamp":1684475155000},"page":"2669-2683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (<scp>CRSwNP<\/scp>): A multicentric observational Phase IV real\u2010life study (<scp>DUPIREAL<\/scp>)"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-7018","authenticated-orcid":false,"given":"Eugenio","family":"De\u00a0Corso","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit A.Gemelli University Hospital Foundation IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-0387","authenticated-orcid":false,"given":"Ernesto","family":"Pasquini","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Ospedale Bellaria Dip Chirurgie Specialistiche AUSL Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-3484","authenticated-orcid":false,"given":"Matteo","family":"Trimarchi","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Head and Neck Department IRCCS San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-273X","authenticated-orcid":false,"given":"Ignazio","family":"La\u00a0Mantia","sequence":"additional","affiliation":[{"name":"Department of Medical\u2014Surgical Sciences and Advanced Technologies E.N.T. Unit P.O. \u201cG. Rodolico\u201d, University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2244-373X","authenticated-orcid":false,"given":"Fabio","family":"Pagella","sequence":"additional","affiliation":[{"name":"Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-4761","authenticated-orcid":false,"given":"Giancarlo","family":"Ottaviano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Otolaryngology Section University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-1177","authenticated-orcid":false,"given":"Massimiliano","family":"Garzaro","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Rhinology Unit Eastern Piedmont University, Maggiore Hospital Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-2117","authenticated-orcid":false,"given":"Carlotta","family":"Pipolo","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Department of Health Sciences ASST Santi Paolo e Carlo Hospital, Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8461-6042","authenticated-orcid":false,"given":"Sara","family":"Torretta","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico\", University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-8034","authenticated-orcid":false,"given":"Veronica","family":"Seccia","sequence":"additional","affiliation":[{"name":"Otolaryngology, Audiology and Phoniatric 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