{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:08:59Z","timestamp":1791857339721,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tissue\u2010resident memory T (T<jats:sub>RM<\/jats:sub>) cells are detrimental in allergic contact dermatitis (ACD), in which they contribute to the chronicity and severity of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the impact of a standard topical corticosteroid (TCS) treatment, triamcinolone acetonide (TA), on the formation, maintenance and reactivation of epidermal T<jats:sub>RM<\/jats:sub> cells in a preclinical model of ACD to 2,4\u2010dinitrofluorobenzene. TA 0.01% was applied at different time points of ACD response and we monitored skin inflammation and tracked CD8+\u2009CD69+\u2009CD103+ T<jats:sub>RM<\/jats:sub> by flow cytometry and RNA sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The impact of TA on T<jats:sub>RM<\/jats:sub> formation depended on treatment regimen: (i) in a preventive mode, that is, in sensitized mice before challenge, TA transiently inhibited the infiltration of effector T cells and the accumulation of T<jats:sub>RM<\/jats:sub> upon hapten challenge. In contrast, (ii) in a curative mode, that is, at the peak of the ACD response, TA blocked skin inflammation but failed to prevent the formation of T<jats:sub>RM<\/jats:sub>. Finally, (iii) in a proactive mode, that is, on previous eczema lesions, TA had no effect on the survival of skin T<jats:sub>RM<\/jats:sub>, but transiently inhibited their reactivation program upon allergen reexposure. Indeed, specific T<jats:sub>RM<\/jats:sub> progressively regained proliferative functions upon TA discontinuation and expanded in the tissue, leading to exaggerated iterative responses. Interestingly, T<jats:sub>RM<\/jats:sub> re\u2010expansion correlated with the decreased clearance of hapten moieties from the skin induced by repeated TA applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that TCS successfully treat ACD inflammation, but are mostly ineffective in impeding the formation and expansion of allergen\u2010specific T<jats:sub>RM<\/jats:sub>, which certainly restricts the induction of lasting tolerance in patients with chronic dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15819","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T10:15:53Z","timestamp":1691144153000},"page":"52-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Topical corticosteroids inhibit allergic skin inflammation but are ineffective in impeding the formation and expansion of resident memory T cells"],"prefix":"10.1111","volume":"79","author":[{"given":"Emi","family":"Ono","sequence":"first","affiliation":[{"name":"CIRI\u2010Centre International de Recherche en Infectiologie, INSERM, U1111, Universit\u00e9 Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, CNRS UMR 5308  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanina","family":"Lenief","sequence":"additional","affiliation":[{"name":"CIRI\u2010Centre International de Recherche en Infectiologie, INSERM, U1111, Universit\u00e9 Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, CNRS UMR 5308  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine\u2010Alexia","family":"Lefevre","sequence":"additional","affiliation":[{"name":"CIRI\u2010Centre International de Recherche en Infectiologie, INSERM, U1111, Universit\u00e9 Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, 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