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In contrast, tape\u2010stripping is a minimally invasive, nonscarring technique to collect skin samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To construct a global AD skin transcriptomic profile comparing tape\u2010strips to whole\u2010skin biopsies, we performed RNA\u2010seq on tape\u2010strips and biopsies taken from the lesional skin of 20 moderate\u2010to\u2010severe AD patients and the skin of 20 controls. Differentially expressed genes (DEGs) were defined by fold\u2010change (FCH) \u22652.0 and false discovery rate &lt;0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We detected 4104 (2513 Up; 1591 Down) and 1273 (546 Up; 727 Down) DEGs in AD versus controls, in tape\u2010strips and biopsies, respectively. Although both techniques captured dysregulation of key immune genes, tape\u2010strips showed higher FCHs for innate immunity (IL\u20101B, IL\u20108), dendritic cell (ITGAX\/CD11C, FCER1A), Th2 (IL\u201013, CCL17, TNFRSF4\/OX40), and Th17 (CCL20, CXCL1) products, while biopsies showed higher upregulation of Th22 associated genes (IL\u201022, S100As) and dermal cytokines (IFN\u2010\u03b3, CCL26). Itch\u2010related genes (IL\u201031, TRPV3) were preferentially captured by tape\u2010strips. Epidermal barrier abnormalities were detected in both techniques, with terminal differentiation defects (FLG2, PSORS1C2) better represented by tape\u2010strips and epidermal hyperplasia changes (KRT16, MKI67) better detected by biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tape\u2010strips and biopsies capture overlapping but distinct features of the AD molecular signature, suggesting their respective utility for monitoring specific AD\u2010related immune, itch, and barrier abnormalities in clinical trials and longitudinal studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15845","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T09:24:52Z","timestamp":1692005092000},"page":"80-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Intrapatient comparison of atopic dermatitis skin transcriptome shows differences between tape\u2010strips and 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