{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:28:02Z","timestamp":1790785682500,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006120","name":"Ministry of the Environment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of prenatal diet on childhood wheezing and subsequent risk of asthma is inconclusive, which may be partly due to the heterogeneity in wheezing phenotypes. We aimed to identify wheeze trajectories in early childhood and to examine their associations with periconceptional maternal diet quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 70,530 mother\u2013child pairs of liveborn singletons from the Japan Environment and Children's Study were analysed. Wheezing was reported by caregivers using a modified International Study of Asthma and Allergies in Childhood questionnaire yearly from 1 to 4\u2009years of age, from which trajectories were derived using group\u2010based trajectory modelling. Maternal diet in the year preceding the first trimester of pregnancy was assessed using a validated food frequency questionnaire; overall diet quality was determined using the balanced diet score based on the Japanese Food Guide Spinning Top. Bayesian inference of multinomial logistic regression models was performed to examine the association between maternal diet quality and wheeze trajectory in early childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified four wheeze trajectories: \u2018never\/infrequent\u2019 (69.1%; reference group), \u2018early\u2010childhood onset\u2019 (6.2%), \u2018transient early\u2019 (16.5%) and \u2018persistent\u2019 (8.2%). After adjustment for confounders, a higher quartile of maternal balanced diet score was associated with a lower risk of belonging to the \u2018transient early\u2019 and \u2018persistent\u2019 wheeze trajectories compared with the \u2018never\/infrequent\u2019 wheeze trajectory by 10% of both. Maternal balanced diet score was not associated with belonging to the \u2018early\u2010childhood onset\u2019 wheeze trajectory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Improving maternal diet quality prior to conception may reduce certain wheeze phenotypes in early childhood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15916","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T10:32:42Z","timestamp":1697625162000},"page":"393-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Periconceptional maternal diet quality and offspring wheeze trajectories: Japan Environment and Children's Study"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-0719","authenticated-orcid":false,"given":"Hitomi","family":"Okubo","sequence":"first","affiliation":[{"name":"Japan Environment and Children's Study Programme Office 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