{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:55:20Z","timestamp":1790787320452,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Drug hypersensitivity reactions (DHRs) to platinum\u2010based drugs are heterogenous and restrict their access, and drug desensitization (DD) has provided a ground\u2010breaking procedure for their re\u2010introduction, although the response is heterogeneous. We aimed to identify the phenotypes, endotypes, and biomarkers of reactions to carboplatin and oxaliplatin and their response to DD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010nine patients presenting with DHRs to oxaliplatin (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200946) and carboplatin (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200933) were evaluated at the Allergy Departments of two tertiary care hospitals in Spain. Patient symptoms, skin testing, biomarkers, and outcomes of 267 DDs were retrospectively analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Oxaliplatin\u2010reactive patients presented with type I (74%), cytokine release reaction (CRR) (11%), and mixed (Mx) (15%) phenotypes. In contrast, carboplatin reactive patients presented with predominantly type I (85%) and Mx (15%) but no CRRs. Out of 267 DDs, breakthrough reactions (BTRs) to oxaliplatin occurred twice as frequently as carboplatin (32% vs. 15%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Phenotype switching from type I to another phenotype was observed in 46% of oxaliplatin DDs compared to 21% of carboplatin DDs. Tryptase was elevated in type I and Mx reactions, and IL\u20106 in CRR and Mx, indicating different mechanisms and endotypes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Carboplatin and oxaliplatin induced three different types of reactions with defined phenotypes and endotypes amendable to DD. Although most of the initial reactions for both were type I, oxaliplatin presented with unique CRR reactions. During DD, carboplatin reactive patients presented mostly type I BTR, while oxaliplatin\u2010reactive patients frequently switched from type I to CRR, providing a critical difference and the need for personalized DD protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.15940","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T07:55:07Z","timestamp":1698911707000},"page":"679-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Differential presentation of hypersensitivity reactions to carboplatin and oxaliplatin: Phenotypes, endotypes, and management with desensitization"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-0507","authenticated-orcid":false,"given":"Teodorikez\u2010Wilfox","family":"Jimenez\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Allergy Section Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL)  Alicante Spain"},{"name":"ARADyAL Spanish Network (RD16\/0006) Instituto de Salud Carlos III (ISCIII), Fundaci\u00f3n Espa\u00f1ola para la Ciencia y la Tecnolog\u00eda (FECyT)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-5678","authenticated-orcid":false,"given":"Leticia","family":"de\u00a0las\u00a0Vecillas","sequence":"additional","affiliation":[{"name":"Allergy Section Marqu\u00e9s de Valdecilla University Hospital\u2010IDIVAL  Santander Spain"},{"name":"Department of Allergy La Paz University Hospital, IdiPAZ  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-4067","authenticated-orcid":false,"given":"Marina","family":"Labella","sequence":"additional","affiliation":[{"name":"ARADyAL Spanish Network (RD16\/0006) Instituto de Salud Carlos III (ISCIII), Fundaci\u00f3n Espa\u00f1ola para la Ciencia y la Tecnolog\u00eda (FECyT)  Madrid Spain"},{"name":"Allergy Clinical Unit Hospital Regional Universitario de M\u00e1laga  M\u00e1laga Spain"},{"name":"Allergy Research Group Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010IBIMA  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna\u2010Marie","family":"Lynch","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Medicine Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie Marie","family":"Besz","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Medicine Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts 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Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Purificaci\u00f3n","family":"Gonz\u00e1lez\u00a0Delgado","sequence":"additional","affiliation":[{"name":"Allergy Section Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL)  Alicante Spain"},{"name":"ARADyAL Spanish Network (RD16\/0006) Instituto de Salud Carlos III (ISCIII), Fundaci\u00f3n Espa\u00f1ola para la Ciencia y la Tecnolog\u00eda (FECyT)  Madrid Spain"},{"name":"Department of Clinical Medicine Miguel Hern\u00e1ndez University  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Allergy Section Marqu\u00e9s de Valdecilla University Hospital\u2010IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Allergy 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