{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:50:00Z","timestamp":1792612200148,"version":"4.5.0"},"reference-count":131,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011824","name":"European Academy of Allergy and Clinical Immunology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in\u00a0vitro assay that mirrors the in\u00a0vivo response, can be a complementary test for many drugs. In this position paper, members of Task Force (TF) \u201cBasophil activation test in the evaluation of Drug Hypersensitivity Reactions\u201d from the European Academy of Allergy and Clinical Immunology (EAACI) present the data from a survey about the use and utility of BAT in IDHRs in Europe. The survey results indicate that there is a great interest for using BAT especially for diagnosing IDHRs. However, there are still main needs, mainly in the standardization of the protocols. Subsequently consensus\u2010based recommendations were formulated for: (i) Technical aspects of BAT in IDHRs including type of sample, management of drugs, flow cytometry protocols, interpretation of the results; and (ii) Drug\u2010specific aspects that should be taken into account when performing BAT in relation to betalactams, neuromuscular blocking agents, fluoroquinolones, chlorhexidine, opioids, radio contrast media, chemotherapeutics, biological agents, nonsteroidal anti\u2010inflammatory drugs, COVID vaccine, and excipients. Moreover, aspects in the evaluation of pediatric population have also been considered. All this indicates that BAT offers the clinician and laboratory a complementary tool for a safe diagnostic for IDHRs, although its place in the diagnostic algorithm depends on the drug class and patient population (phenotype, geography, and age). The standardization of BAT is important for generalizing this method beyond the individual laboratory.<\/jats:p>","DOI":"10.1111\/all.15957","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T22:01:37Z","timestamp":1702418497000},"page":"580-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Flow\u2010based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-8077","authenticated-orcid":false,"given":"C.","family":"Mayorga","sequence":"first","affiliation":[{"name":"Allergy Unit Hospital Regional Universitario de M\u00e1laga and Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma BIONAND  M\u00e1laga Spain"},{"name":"RETICS Asma reacciones adversas y al\u00e9rgicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-513X","authenticated-orcid":false,"given":"G. E.","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of chest disease, Division of Allergy &amp; Immunology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0549-9720","authenticated-orcid":false,"given":"M.","family":"Pascal","sequence":"additional","affiliation":[{"name":"RETICS Asma reacciones adversas y al\u00e9rgicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI)  Madrid Spain"},{"name":"Immunology Department Centre de Diagn\u00f2stic Biom\u00e8dic, Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-7931","authenticated-orcid":false,"given":"H. J.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Department of Clinical Immunology Aarhus University and Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-6491","authenticated-orcid":false,"given":"B.","family":"Eberlein","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein School of Medicine, Technical University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-471X","authenticated-orcid":false,"given":"M. J.","family":"Torres","sequence":"additional","affiliation":[{"name":"Allergy Unit Hospital Regional Universitario de M\u00e1laga and Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma BIONAND  M\u00e1laga Spain"},{"name":"RETICS Asma reacciones adversas y al\u00e9rgicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI)  Madrid Spain"},{"name":"Medicine Department Malaga University  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-3681","authenticated-orcid":false,"given":"K.","family":"Brockow","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein School of Medicine, Technical University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-4501","authenticated-orcid":false,"given":"L. H.","family":"Garvey","sequence":"additional","affiliation":[{"name":"Allergy Clinic, Department of Dermatology and Allergy Herlev and Gentofte Hospital, University of Copenhagen and Department of Clinical Medicine, University of Copenhagen  Kobenhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-1589","authenticated-orcid":false,"given":"A.","family":"Barbaud","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, AP\u2010HP.Sorbonne Universit\u00e9, H\u00f4pital Tenon, D\u00e9partement de dermatologie et\u00a0allergologie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3358-3578","authenticated-orcid":false,"given":"R.","family":"Madrigal\u2010Burgaleta","sequence":"additional","affiliation":[{"name":"Allergy &amp; Severe Asthma Service St Bartholomew's Hospital, Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3130-095X","authenticated-orcid":false,"given":"J. C.","family":"Caubet","sequence":"additional","affiliation":[{"name":"Department of Women\u2010Children\u2010Teenagers University Hospital of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0672-7529","authenticated-orcid":false,"given":"D. G.","family":"Ebo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and the Infla\u2010Med Centre of Excellence, Antwerp (Belgium) and Immunology, Allergology, Rheumatology Antwerp University Hospital, University of Antwerp  Antwerp Belgium"},{"name":"Department of Immunology and Allergology AZ Jan Palfijn Gent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13765"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-48551-7.00003-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.08.045"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0105-4538.2001.00001.x-i8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12886"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2021.113101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.02.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23136992"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.09.022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12698"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22443"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03277.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14252"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14122"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15090"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200602-197ST"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.060"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23845"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13761"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03426.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.09.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.5.2760"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.06.003"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2011.09.003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003679"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02460.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12468"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01094.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.12.001"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15610"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02960.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13236"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02004.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01305.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14747"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.10.066"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01713.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.08.009"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03237.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70367-2"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343023"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02245.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02110.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.11.032"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.08.017"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13817"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00096.x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2013.5.6.383"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00924.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21074"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.02.024"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.11.006"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0590"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23329"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290301"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0696-4_16"},{"issue":"8","key":"e_1_2_10_58_1","first-page":"525","article-title":"Enhancement of basophil histamine release by interleukin\u20103: reduced effect in atopic subjects","volume":"51","author":"Miadonna A","year":"1996","journal-title":"Allergy"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077351"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-014-0007-3"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.027"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.10.050"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328211"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02213.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2021.113050"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.12932\/AP\u2010250620\u20100890"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2004.051"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40981-022-00581-w"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15148"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.12.020"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.01.020"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b12-00150"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.08.031"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.05.037"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.01.002"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.01.004"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.02.008"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12344"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2004.00591.x"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12448"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2017.9.4.347"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-019-0858-2"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.01.033"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12466"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.06.016"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1204000204"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.12.002"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14656"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12589"},{"issue":"6","key":"e_1_2_10_90_1","first-page":"537","article-title":"Basophil activation test in a case of systemic hypersensitivity reaction to infliximab with good tolerance to another anti\u2010TNF\u2010alpha agent (adalimumab)","volume":"20","author":"Manso L","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.04.034"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14698"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0350"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12344"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13073"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.12.005"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514263"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15278"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.02.031"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-017-0360-1"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12314"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2018.1448990"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.2298\/SARH1204233A"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.02.2012.5797"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15907"},{"issue":"2","key":"e_1_2_10_106_1","first-page":"91","article-title":"Diagnosis of immediate\u2010type beta\u2010lactam allergy in\u00a0vitro by flow\u2010cytometric basophil activation test and sulfidoleukotriene production: A multicenter study","volume":"19","author":"De Week AL","year":"2009","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23050997"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.02.007"},{"issue":"2","key":"e_1_2_10_109_1","first-page":"84","article-title":"Selective hypersensitivity to cefazolin and contribution of the basophil activation test","volume":"49","author":"Almeida JP","year":"2017","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-018-2555-z"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.04.051"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12099"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12214"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01929.x"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444798"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2001.5156"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04112.x"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.02.024"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490313"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12538"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14497"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14542"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1159\/000435812"},{"issue":"4","key":"e_1_2_10_124_1","first-page":"278","article-title":"Basophil activation and sulfidoleukotriene production in patients with immediate allergy to betalactam antibiotics and negative skin tests","volume":"14","author":"Gamboa PM","year":"2004","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.08.016"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2020.01.006"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082586"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70386-6"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.04086.x"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.00978.x"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02569.x"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21226"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.15957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T13:31:37Z","timestamp":1709213497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.15957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,12]]},"references-count":131,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/all.15957"],"URL":"https:\/\/doi.org\/10.1111\/all.15957","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,12]]},"assertion":[{"value":"2023-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}