{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:34:09Z","timestamp":1768325649996,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HV22C0233; Health Fellowship Foundation of South Korea (2022)"],"award-info":[{"award-number":["HV22C0233; Health Fellowship Foundation of South Korea (2022)"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vaccine\u2010associated anaphylaxis is a rare but life\u2010threatening reaction that occurs within minutes to hours of exposure to allergens. As studies utilizing large\u2010scale data to investigate this topic are limited, further research is needed to assess its burden, long\u2010term trends, and associated risk factors so as to gain a comprehensive understanding of vaccine\u2010associated anaphylaxis globally. Therefore, this study aimed to investigate the global burden of vaccine\u2010associated anaphylaxis and related vaccines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study utilized the World Health Organization International Pharmacovigilance Database, in which reports of vaccine\u2010associated anaphylaxis between 1967 and 2023 were obtained (total reports\u2009=\u2009131,255,418). We estimated the global reporting counts, reported odds ratio (ROR), and information component (IC) to identify the relationship between 19 vaccines and associated anaphylaxis in 156 countries and territories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 31,676 reports of vaccine\u2010associated anaphylaxis among 363,290 reports of all\u2010cause anaphylaxis. The cumulative number of reports on vaccine\u2010associated anaphylaxis has gradually increased over time, with a dramatic increase after 2020, owing to reports of COVID\u201019 mRNA vaccine\u2010associated anaphylaxis. The typhoid vaccines were associated with the most anaphylactic reports (ROR: 4.35; IC<jats:sub>0.25<\/jats:sub>: 1.86), followed by encephalitis (3.27; 1.45), hepatitis B (2.69; 1.30), cholera (2.65; 0.54), hepatitis A (2.44; 1.12), influenza (2.36; 1.16), inactivated whole\u2010virus COVID\u201019 (2.21; 1.02), and COVID\u201019 mRNA vaccines (1.89; 0.79). In terms of age\u2010 and sex\u2010specific risks, vaccine\u2010associated anaphylaxis reports develop more frequently in females and at young ages. The Ad5\u2010vectored COVID\u201019 vaccine anaphylaxis reports were associated with the highest fatality rate (15.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although multiple vaccines are associated with various spectra and risks of anaphylaxis, clinicians should recognize the possibility of anaphylaxis occurring with all vaccines, particularly the COVID\u201019 mRNA and inactivated whole\u2010virus COVID\u201019 vaccines, and consider the risk factors associated with vaccine anaphylaxis reports. Further studies are warranted to identify better ways of preventing vaccine\u2010associated anaphylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.15968","type":"journal-article","created":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T14:49:45Z","timestamp":1702219785000},"page":"690-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Global burden of vaccine\u2010associated anaphylaxis and their related vaccines, 1967\u20132023: A comprehensive analysis of the international pharmacovigilance database"],"prefix":"10.1111","volume":"79","author":[{"given":"Kyeonghun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatrics Chung\u2010Ang University Hospital  Seoul South 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Medical Center, Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-3468","authenticated-orcid":false,"given":"Nikolaos G.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Allergy Department, 2nd Paediatric Clinic National Kapodistrian University of Athens  Athens Greece"},{"name":"Lydia Becker Institute of Immunology &amp; Inflammation, University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Rahmati","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences Lorestan University  Khoramabad Iran"},{"name":"Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities Vali\u2010E\u2010Asr University of Rafsanjan  Rafsanjan 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