{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:54:37Z","timestamp":1792814077793,"version":"4.5.0"},"reference-count":76,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Following the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) treatment algorithm for chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), patients suffering from severe uncontrolled CRSwNP are recommended to receive oral corticosteroids, (revision) sinus surgery, systemic biologicals and\/or aspirin treatment after desensitization (ATAD). Given the major differences in indications, outcomes, practical considerations, risks and costs of these key pillars of treatment, there is a growing need to define criteria for each treatment option and list the clinically relevant and major considerations for them. This EUFOREA document therefore provides an expert panel overview of the expected outcomes, specific considerations and (contra)indications of the five major treatment arms of severe uncontrolled CRSwNP: oral corticosteroids, primary and revision sinus surgery, biological treatment and ATAD. This overview of treatment considerations is needed to allow physicians and patients to consider the different options in the context of providing optimal and personalized care for severe uncontrolled CRSwNP. In conclusion, the five major treatment options for severe uncontrolled CRSwNP have intrinsic advantages, specific indications and considerations that are of importance to the patient, the physician and the society. This EUFOREA statement supports the unmet need to define criteria for the indication of every treatment pillar of CRSwNP.<\/jats:p>","DOI":"10.1111\/all.15982","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T10:01:25Z","timestamp":1702893685000},"page":"1123-1133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["EUFOREA\/EPOS2020 statement on the clinical considerations for chronic rhinosinusitis with nasal polyps care"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6898-688X","authenticated-orcid":false,"given":"Peter W.","family":"Hellings","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Allergy and Clinical Immunology Research unit KU Leuven  Leuven Belgium"},{"name":"Clinical Department of Otorhinolaryngology, Head and Neck Surgery University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Otorhinolaryngology, Upper airways research laboratory Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam","family":"Alobid","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Unit, ENT Department, Hospital Cl\u00ednic Universitat de Barcelona  Barcelona Spain"},{"name":"Clinical and Experimental Respiratory Immunoallergy Institut d'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Center of Biomedical Research in Respiratory Diseases (CIBERES)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma T.","family":"Anselmo\u2010Lima","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Ophthalmology, Otorhinolaryngology, Head and Neck Surgery Ribeirao Preto Medical School\u2010University of Sao Paulo  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-9833","authenticated-orcid":false,"given":"Manuel","family":"Bernal\u2010Sprekelsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Barcelona  Barcelona Spain"},{"name":"Department of Otorhinolaryngology Hospital Clinic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3441-8099","authenticated-orcid":false,"given":"Leif","family":"Bjermer","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine &amp; Allergology Institute for Clinical Science, Skane University Hospital, Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Caulley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Ottawa  Ottawa Ontario Canada"},{"name":"Clinical Epidemiology Program The Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Institut for Klinisk Medicin Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5117-4073","authenticated-orcid":false,"given":"Adam","family":"Chaker","sequence":"additional","affiliation":[{"name":"Dept. of Otorhinolaryngology and Center for Allergy and Environment (ZAUM), TUM School of Medicine Klinikum rechts der Isar, Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2369-993X","authenticated-orcid":false,"given":"Jannis","family":"Constantinidis","sequence":"additional","affiliation":[{"name":"1st Department of Otorhinolaryngology, Medical School, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-495X","authenticated-orcid":false,"given":"Diego M.","family":"Conti","sequence":"additional","affiliation":[{"name":"The European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-7018","authenticated-orcid":false,"given":"Eugenio","family":"De\u00a0Corso","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head and Neck Surgery, Rhinology A. 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