{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:27:04Z","timestamp":1789216024882,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adult asthma is complex and incompletely understood. Plasma proteomics is an evolving technique that can both generate biomarkers and provide insights into disease mechanisms. We aimed to identify plasma proteomic signatures of adult asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Protein abundance in plasma was measured in individuals from the Agricultural Lung Health Study (ALHS) (761 asthma, 1095 non\u2010case) and the Atherosclerosis Risk in Communities study (470 asthma, 10,669 non\u2010case) using the SOMAScan 5K array. Associations with asthma were estimated using covariate adjusted logistic regression and meta\u2010analyzed using inverse\u2010variance weighting. Additionally, in ALHS, we examined phenotypes based on both asthma and seroatopy (asthma with atopy (<jats:italic>n<\/jats:italic>\u2009=\u2009207), asthma without atopy (<jats:italic>n<\/jats:italic>\u2009=\u2009554), atopy without asthma (<jats:italic>n<\/jats:italic>\u2009=\u2009147), compared to neither (<jats:italic>n<\/jats:italic>\u2009=\u2009948)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Meta\u2010analysis of 4860 proteins identified 115 significantly (FDR&lt;0.05) associated with asthma. Multiple signaling pathways related to airway inflammation and pulmonary injury were enriched (FDR&lt;0.05) among these proteins. A proteomic score generated using machine learning provided predictive value for asthma (AUC\u2009=\u20090.77, 95% CI\u2009=\u20090.75\u20130.79 in training set; AUC\u2009=\u20090.72, 95% CI\u2009=\u20090.69\u20130.75 in validation set). Twenty proteins are targeted by approved or investigational drugs for asthma or other conditions, suggesting potential drug repurposing. The combined asthma\u2010atopy phenotype showed significant associations with 20 proteins, including five not identified in the overall asthma analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This first large\u2010scale proteomics study identified over 100 plasma proteins associated with current asthma in adults. In addition to validating previous associations, we identified many novel proteins that could inform development of diagnostic biomarkers and therapeutic targets in asthma management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.16000","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T07:29:47Z","timestamp":1706081387000},"page":"643-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Plasma protein signatures of adult asthma"],"prefix":"10.1111","volume":"79","author":[{"given":"Gordon J.","family":"Smilnak","sequence":"first","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-0179","authenticated-orcid":false,"given":"Yura","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health The University of Texas Health Science Center at Houston Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijnan","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annah B.","family":"Wyss","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie D.","family":"White","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"},{"name":"GenOmics and Translational Research Center, Biostatistics and Epidemiology Division RTI International Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinjini","family":"Sikdar","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"},{"name":"Department of Mathematics and Statistics Old Dominion University Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Jin","sequence":"additional","affiliation":[{"name":"Westat, Inc. 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