{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:17:51Z","timestamp":1790075871847,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central and Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern European countries with a standardized approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe sensitization profiles and clinical phenotypes of pollen allergic patients in nine Southern European cities with a uniform methodological approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within the @IT.2020 multicenter observational study, pediatric and adult patients suffering from SAR were recruited in nine urban study centers located in seven countries. Clinical questionnaires, skin prick tests (SPT) and specific IgE (sIgE) tests with a customized multiplex assay (Euroimmun Labordiagnostika, L\u00fcbeck, Germany) were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred forty\u2010eight children (mean age 13.1\u2009years, SD: 2.4\u2009years) and 467 adults (mean age 35.7\u2009years SD: 10.0\u2009years) with a predominantly moderate to severe, persistent phenotype of SAR were recruited. Grass pollen major allergenic molecules (Phl p\u00a01 and\/or Phl p 5) ranged among the top three sensitizers in all study centers. Sensitization profiles were very heterogeneous, considering that patients in Rome were highly poly\u2010sensitized (sIgE to 3.8 major allergenic molecules per patient), while mono\u2010sensitization was prominent and heterogeneous in other cities, such as Marseille (sIgE to Cup a 1: <jats:italic>n<\/jats:italic>\u2009=\u200955\/80, 68.8%) and Messina (sIgE to Par j 2: <jats:italic>n<\/jats:italic>\u2009=\u200947\/82, 57.3%). Co\u2010sensitization to perennial allergens, as well as allergic comorbidities also broadly varied between study centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Southern European countries, pollen allergy is heterogeneous in terms of sensitization profiles and clinical manifestations. Despite the complexity, a unique molecular, multiplex, and customized in\u2010vitro IgE test detected relevant sensitization in all study centers. Nevertheless, this geographical diversity in pollen allergic patients imposes localized clinical guidelines and study protocols for clinical trials of SAR in this climatically complex region.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.16029","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:25:40Z","timestamp":1707294340000},"page":"908-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries\u2014The @IT.2020 multicenter study"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-3260","authenticated-orcid":false,"given":"S.","family":"Dramburg","sequence":"first","affiliation":[{"name":"Department of Pediatric Respiratory Care, Immunology and Intensive Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Grittner","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Clinical Epidemiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Potapova","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Care, Immunology and Intensive Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Travaglini","sequence":"additional","affiliation":[{"name":"Department of Biology Tor Vergata University  Rome Italy"},{"name":"Italian Aerobiology Monitoring Network \u2013 Italian Aerobiology Association  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tripodi","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Unit Sandro Pertini Hospital  Rome Italy"},{"name":"Allergolology Service Policlinico Casilino  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arasi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Care, Immunology and Intensive Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Pediatric Allergology Unit, Department of Pediatric Medicine Bambino Ges\u00f9 Children's Research Hospital (IRCCS)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pelosi","sequence":"additional","affiliation":[{"name":"TPS Production srl  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Acar\u00a0\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Aggelidis","sequence":"additional","affiliation":[{"name":"Allergy Unit, 2nd Department of Dermatology and Venereology National and Kapodistrian University of Athens, University Hospital \"Attikon\"  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Barbalace","sequence":"additional","affiliation":[{"name":"Allergy Unit, Department of Pediatrics University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bourgoin","sequence":"additional","affiliation":[{"name":"Department of Pneumonology and Allergy La Timone Hospital, APHM, Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bregu","sequence":"additional","affiliation":[{"name":"Department of Allergology and Clinical Immunology UHC Mother Teresa, Medical University Tirana  Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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