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Fluctuations in the composition of the skin microbiome have been observed in atopic dermatitis (AD) and food allergy (FA), particularly in early life, established disease, and associated with therapeutics. However, AD is a multifactorial disease characterized by skin barrier aberrations modulated by genetics, immunology, and environmental influences, thus the skin microbiome is not the sole feature of this disease. Future research should focus on mechanistic understanding of how early\u2010life skin microbial shifts may influence AD and FA onset, to guide potential early intervention strategies or as microbial biomarkers to identify high\u2010risk infants who may benefit from possible microbiome\u2010based biotherapeutic strategies. Harnessing skin microbes as AD biotherapeutics is an emerging field, but more work is needed to investigate whether this approach can lead to sustained clinical responses.<\/jats:p>","DOI":"10.1111\/all.16044","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T03:34:07Z","timestamp":1706931247000},"page":"1470-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The skin microbiome in pediatric atopic dermatitis and food allergy"],"prefix":"10.1111","volume":"79","author":[{"given":"Elizabeth Huiwen","family":"Tham","sequence":"first","affiliation":[{"name":"Khoo Teck Puat\u2010National University Children's Medical Institute National University Health System (NUHS)  Singapore City Singapore"},{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine National University of Singapore (NUS)  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Chia","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore (GIS) Agency for Science, Technology and Research (A*STAR)  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Riggioni","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine National University of Singapore (NUS)  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore (GIS) Agency for Science, Technology and Research (A*STAR)  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-7365","authenticated-orcid":false,"given":"John E. 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