{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:00:43Z","timestamp":1785855643135,"version":"3.56.0"},"reference-count":130,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tape\u2010strips, a minimally invasive method validated for the evaluation of several skin diseases, may help identify asthma\u2010specific biomarkers in the skin of children with allergic asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin tape\u2010strips were obtained and analyzed with RNA\u2010Seq from children with moderate allergic asthma (MAA) (<jats:italic>n<\/jats:italic>\u2009=\u200911, mean age 7.00; SD\u2009=\u20091.67), severe allergic asthma (SAA) (<jats:italic>n<\/jats:italic>\u2009=\u20099, mean age 9.11; SD\u2009=\u20092.37), and healthy controls (HCs) (<jats:italic>n<\/jats:italic>\u2009=\u200912, mean age 7.36; SD\u2009=\u20092.03). Differentially expressed genes (DEGs) were identified by fold change \u22652 with a false discovery rate &lt;0.05. Transcriptomic biomarkers were analyzed for their accuracy in distinguishing asthma from HCs, their relationships with asthma\u2010related outcomes (exacerbation rate, lung function\u2010FEV1, IOS\u2010R5\u201020, and lung inflammation\u2010FeNO), and their links to skin (barrier and immune response) and lung (remodeling, metabolism, aging) pathogenetic pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RNA\u2010Seq captured 1113 in MAA and 2117 DEGs in SAA. Epidermal transcriptomic biomarkers for terminal differentiation (FLG\/filaggrin), cell adhesion (CDH19, JAM2), lipid biosynthesis\/metabolism (ACOT2, LOXL2) were significantly downregulated. Gene set variation analysis revealed enrichment of Th1\/IFN\u03b3 pathways (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). MAA and SAA shared downregulation of G\u2010protein\u2010coupled receptor (OR4A16, TAS1R3), upregulation of TGF\u2010\u03b2\/ErbB signaling\u2010related (ACVR1B, EGFR, ID1\/2), and upregulation of mitochondrial\u2010related (HIGD2A, VDAC3, NDUFB9) genes. Skin transcriptomic biomarkers correlated with the annualized exacerbation rate and with lung function parameters. A two\u2010gene classifier (TSSC4\u2010FAM212B) was able to differentiate asthma from HCs with 100% accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tape\u2010strips detected epithelial barrier and asthma\u2010associated signatures in normal\u2010appearing skin from children with allergic asthma and may serve as an alternative to invasive approaches for evaluating asthma endotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.16060","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:35:35Z","timestamp":1708428935000},"page":"1516-1530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Transcriptomic evaluation of skin tape\u2010strips in children with allergic asthma uncovers epidermal barrier dysfunction and asthma\u2010associated biomarkers abnormalities"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7948-8536","authenticated-orcid":false,"given":"Ester","family":"Del\u00a0Duca","sequence":"first","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"},{"name":"Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4050-6773","authenticated-orcid":false,"given":"Dante","family":"Dahabreh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8108-3631","authenticated-orcid":false,"given":"Madeline","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-9416","authenticated-orcid":false,"given":"Jonathan","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-1976","authenticated-orcid":false,"given":"Joel Correa","family":"Da\u00a0Rosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-280X","authenticated-orcid":false,"given":"Grace","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-9854","authenticated-orcid":false,"given":"Paola","family":"Facheris","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"},{"name":"Department of Dermatology IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-6950","authenticated-orcid":false,"given":"Pedro Jes\u00fas","family":"G\u00f3mez\u2010Arias","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"},{"name":"Department of Dermatology Reina Sof\u00eda University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC)  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4692-6338","authenticated-orcid":false,"given":"Annie","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-2789","authenticated-orcid":false,"given":"Vivian","family":"Utti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9199-9487","authenticated-orcid":false,"given":"Amira","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6208-0489","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-6747","authenticated-orcid":false,"given":"Yeriel D.","family":"Estrada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-0569","authenticated-orcid":false,"given":"Alexandru","family":"Laculiceanu","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Transylvania University  Brasov Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-364X","authenticated-orcid":false,"given":"Ioana","family":"Agache","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Transylvania University  Brasov Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-324X","authenticated-orcid":false,"given":"Emma","family":"Guttman\u2010Yassky","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at the Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.12.04052"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02865.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15807"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19627"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02832.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.030262"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00239.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.741"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328013d61b"},{"issue":"2","key":"e_1_2_11_12_1","article-title":"The correlation between fractional exhaled nitric oxide (FeNO), blood eosinophil count, immunoglobulin E levels, and Spirometric values in patients with asthma","volume":"15","author":"Al Ghobain MO","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-023-00330-1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0213-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12958"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00050-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14645"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-017-0219-4"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2016.04.011"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124611"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000134"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14582"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12268"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15917"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-12-11"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.031"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-015-0037-5"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15240"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00538-7"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14318"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.03.050"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13935"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.2983"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.09.038"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2022.02.008"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.048"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15423"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14490"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav2685"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.08.041"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13749"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15845"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-2-r29"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0384-y"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.003"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.042"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.013"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.031"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15741"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.037"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.02.035"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01768"},{"key":"e_1_2_11_56_1","first-page":"1","article-title":"Meta\u2010analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways","volume":"8","author":"Ewald DA","year":"2015","journal-title":"BMC Med Genet"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14154"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.235"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0247OC"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200907-067DP"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04826-y"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200721020-00003"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1668"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76658"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.577201"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.046"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0571-8"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.02.002"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-39"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00115412"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1176-x"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.03.005"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040342"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.09.002"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2017.1343172"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-0310-x"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20156123"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4352"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.014647"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.08.011"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.655285"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp073"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr260"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.674739"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.581906"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvy100"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500711102"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05125-x"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01732-8"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-022-00308-9"},{"issue":"4","key":"e_1_2_11_91_1","first-page":"450","article-title":"New directions in understanding atopic march starting from atopic dermatitis","volume":"9","author":"Maiello N","year":"2022","journal-title":"Children (Basel)"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0795-y"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12452"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1141798"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-214476"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9953234"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0730-x"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00625-2021"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00301.2014"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-187"},{"issue":"4","key":"e_1_2_11_101_1","first-page":"1643","article-title":"Bioinformatic analysis of next\u2010generation sequencing data to identify dysregulated genes in fibroblasts of idiopathic pulmonary fibrosis","volume":"43","author":"Sheu C\u2010C","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.10.21.512955"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202007152"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14421"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1124"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.01.001"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-114"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1730"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9906130"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.020"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.054"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80911"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00547.2017"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201402-0314OC"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3030268"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.09.007"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14425"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2021.100033"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.01.035"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102946"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2649-z"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes9020109"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0499OC"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13085"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203002"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.143"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01148"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38061"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.429"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46166"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028183"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.16060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T07:40:55Z","timestamp":1717141255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.16060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":130,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/all.16060"],"URL":"https:\/\/doi.org\/10.1111\/all.16060","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]},"assertion":[{"value":"2023-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}