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In addition, correlation of the altered metabolome with gut microbiome was analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ovalbumin\u2010sensitized and egg\u2010white diet\u2010fed (OVA\/EW) BALB\/c WT mice developed moderate AE, whereas OVA\/EW IgEki mice induced more aggravated intestinal inflammation with enhanced eosinophil accumulation. Untargeted metabolomics detected the increased levels of N\u2010tau\u2010methylhistamine and 2,3\u2010butanediol, and reduced levels of butyric acid in faeces and\/or sera of OVA\/EW IgEki mice, which was accompanied with reduced Clostridium and increased Lactobacillus at the genus level. Non\u2010sensitized and egg\u2010white diet\u2010fed (NC\/EW) WT mice did not exhibit any signs of AE, whereas NC\/EW IgEki mice developed marginal degrees of AE. Compared to NC\/EW WT mice, enhanced levels of lysophospholipids, sphinganine and sphingosine were detected in serum and faecal samples of NC\/EW IgEki mice. In addition, several associations of altered metabolome with gut microbiome\u2014for example Akkermansia with lysophosphatidylserine\u2014were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that high\u2010IgE levels alter intestinal and systemic levels of endogenous and microbiota\u2010associated metabolites in experimental AE. This study contributes to deepening the knowledge of molecular mechanisms for the development of AE and provides clues to advance diagnostic and therapeutic strategies of allergic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.16202","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T06:55:48Z","timestamp":1719212148000},"page":"3430-3447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of high\u2010IgE levels on metabolome and microbiome in experimental allergic enteritis"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-6313","authenticated-orcid":false,"given":"Elisa","family":"Zubeldia\u2010Varela","sequence":"first","affiliation":[{"name":"Institute of Applied Molecular Medicine (IMMA), Department of Basic Medical Sciences, Facultad de Medicina Universidad San Pablo\u2010CEU, CEU Universities  Madrid 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