{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:17:12Z","timestamp":1788185832979,"version":"build-2803163510"},"reference-count":228,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Derived from the myeloid lineage, granulocytes, including basophils, eosinophils, and neutrophils, along with mast cells, play important, often disparate, roles across the allergic disease spectrum. While these cells and their mediators are commonly associated with allergic inflammation, they also exhibit several functions either promoting or restricting tumor growth. In this Position Paper we discuss common granulocyte and mast cell features relating to immunomodulatory functions in allergy and in cancer. We highlight key mechanisms which may inform cancer treatment and propose pertinent areas for future research. We suggest areas where understanding the communication between granulocytes, mast cells, and the tumor microenvironment, will be crucial for identifying immune mechanisms that may be harnessed to counteract tumor development. For example, a comprehensive understanding of allergic and immune factors driving distinct neutrophil states and those mechanisms that link mast cells with immunotherapy resistance, might enable targeted manipulation of specific subpopulations, leading to precision immunotherapy in cancer. We recommend specific areas of investigation in AllergoOncology and knowledge exchange across disease contexts to uncover pertinent reciprocal functions in allergy and cancer and allow therapeutic manipulation of these powerful cell populations. These will help address the unmet needs in stratifying and managing patients with allergic diseases and cancer.<\/jats:p>","DOI":"10.1111\/all.16246","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T05:18:01Z","timestamp":1721625481000},"page":"2319-2345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Granulocytes and mast cells in AllergoOncology\u2014Bridging allergy to cancer: An <scp>EAACI<\/scp> position paper"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0549-9720","authenticated-orcid":false,"given":"Mariona","family":"Pascal","sequence":"first","affiliation":[{"name":"Immunology Department, CDB Hospital Cl\u00ednic de Barcelona; Institut d'Investigaci\u00f3 Biom\u00e8dica August Pi i Sunyer (IDIBAPS), Universitat de Barcelona  Barcelona Spain"},{"name":"Department of Medicine Universitat de Barcelona  Barcelona Spain"},{"name":"RETICS Asma, reacciones adversas y al\u00e9rgicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI) Instituto de Salud Carlos III (ISCIII)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-4160","authenticated-orcid":false,"given":"Heather J.","family":"Bax","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic &amp; Medical Biosciences &amp; KHP Centre for Translational Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-8813","authenticated-orcid":false,"given":"Christoph","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology RKM740 Interdisciplinary Clinics  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0351-6937","authenticated-orcid":false,"given":"Rodolfo","family":"Bianchini","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology Medical University Vienna  Vienna Austria"},{"name":"The interuniversity Messerli Research Institute University of Veterinary Medicine Vienna, Medical University Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6451-0163","authenticated-orcid":false,"given":"Mariana","family":"Castells","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Drug Hypersensitivity and Desensitization Center, Mastocytosis Center Brigham and Women's Hospital; Harvard Medical School  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-9234","authenticated-orcid":false,"given":"Jitesh","family":"Chauhan","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic &amp; Medical Biosciences &amp; KHP Centre for Translational Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-5678","authenticated-orcid":false,"given":"Leticia","family":"De\u00a0las\u00a0Vecillas","sequence":"additional","affiliation":[{"name":"Department of Allergy La Paz University Hospital, IdiPAZ  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-8226","authenticated-orcid":false,"given":"Karin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Division of Allergy, Department of Dermatology University Hospital Basel and University of Basel  Basel Switzerland"},{"name":"Department of Biomedicine University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-2798","authenticated-orcid":false,"given":"Elena Izquierdo","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Facultad de Medicina, Universidad San Pablo\u2010CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe Institute of Applied Molecular Medicine Instituto de Medicina Molecular Aplicada Nemesio D\u00edez (IMMA)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-3672","authenticated-orcid":false,"given":"Uta","family":"Jappe","sequence":"additional","affiliation":[{"name":"Division of Clinical and Molecular Allergology, Priority Research Area Chronic Lung Diseases, Research Center Borstel, Leibniz Lung Center German Center for Lung Research (DZL), Airway Research Center North (ARCN)  Borstel Germany"},{"name":"Interdisciplinary Allergy Outpatient Clinic, Department of Pneumology University of Luebeck  Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-0507","authenticated-orcid":false,"given":"Teodorikez\u2010Wilfox","family":"Jimenez\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Allergy Section Dr. Balmis General University Hospital; Alicante Institute for Health and Biomedical Research (ISABIAL)  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-9820","authenticated-orcid":false,"given":"Edward","family":"Knol","sequence":"additional","affiliation":[{"name":"Departments Center of Translational Immunology and Dermatology\/Allergology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-2810","authenticated-orcid":false,"given":"Francesca","family":"Levi\u2010Schaffer","sequence":"additional","affiliation":[{"name":"Pharmacology and Experimental Therapeutics Unit Institute for Drug Research, School of Pharmacy, Faculty of Medicine. The Hebrew University of Jerusalem, Ein Kerem Campus  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-8077","authenticated-orcid":false,"given":"Cristobalina","family":"Mayorga","sequence":"additional","affiliation":[{"name":"RETICS Asma, reacciones adversas y al\u00e9rgicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI) Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Allergy Unit and Research Laboratory Hospital Regional Universitario de M\u00e1laga\u2010HRUM, Instituto de investigaci\u00f3n Biom\u00e9dica de M\u00e1laga \u2010IBIMA\u2010Plataforma BIONAND  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7986-0761","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Poli","sequence":"additional","affiliation":[{"name":"Neuro\u2010Immunology Group, Department of Cancer Research Luxembourg Institute of Health  Luxembourg Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-7960","authenticated-orcid":false,"given":"Frank","family":"Redegeld","sequence":"additional","affiliation":[{"name":"Division of Pharmacology Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7805-1436","authenticated-orcid":false,"given":"Alexandra F.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"},{"name":"Peter Gorer Department of Immunobiology School of Immunology and Microbial Sciences, King's College London  London UK"},{"name":"Children's Allergy Service Evelina London Children's Hospital, Guy's and St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-5765","authenticated-orcid":false,"given":"Erika","family":"Jensen\u2010Jarolim","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology Medical University Vienna  Vienna Austria"},{"name":"The interuniversity Messerli Research Institute University of Veterinary Medicine Vienna, Medical University Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4100-7810","authenticated-orcid":false,"given":"Sophia N.","family":"Karagiannis","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic &amp; Medical Biosciences &amp; KHP Centre for Translational Medicine King's College London  London UK"},{"name":"Breast Cancer Now Research Unit School of Cancer &amp; Pharmaceutical Sciences, King's College London, Guy's Cancer Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13119"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15889"},{"key":"e_1_2_12_4_1","volume-title":"Cellular Molecular Immunology","author":"Abbas APS","year":"2021"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13311"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15255"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030438"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.871390"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.2023057001172024c"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncrna.2020.12.002"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1201\/b14248-14"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063119"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12627"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137091"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420529908998730"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201456R"},{"issue":"11","key":"e_1_2_12_17_1","article-title":"Circadian features of neutrophil biology","volume":"3","author":"Aroca\u2010Crevill\u00e9n A","year":"2020","journal-title":"Front Immunol"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-021-00721-2"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1009064"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.006"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15751"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02504-4"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00762-2"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00703-y"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15980"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.922945"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1762"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00718-5"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15884"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14747"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90094-5"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2011.09.003"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13984"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14022"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06188-0"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06362-4"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat1479"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.005"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.07.003"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.05.006"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.03.513"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.105"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4332"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43568"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803894"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-019-08753-w"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20600-7"},{"issue":"6","key":"e_1_2_12_48_1","first-page":"1025","article-title":"Poor response to neoadjuvant chemotherapy correlates with mast cell infiltration in inflammatory breast cancer. Cancer","volume":"7","author":"Reddy SM","year":"2019","journal-title":"Immunol Res"},{"issue":"21","key":"e_1_2_12_49_1","first-page":"2929","article-title":"Controversial role of mast cells in NSCLC tumor progression and angiogenesis. Thorac","volume":"13","author":"Longo V","year":"2022","journal-title":"Cancer"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100070"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1504729"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-415638"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.794974"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-49270-0_9"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12670"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.05.042"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01445"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011941"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061270"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0385"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030349"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09673-3"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1015263"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.04.045"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0283-9"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101270"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04418-7"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2020.1859732"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-0839"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06966-3"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-18-0494"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85664"},{"issue":"10","key":"e_1_2_12_73_1","first-page":"004016","article-title":"Ultrastructural evidence of eosinophil clustering and ETosis in association with damage to single tumour cells in a case of poorly cohesive NOS gastric carcinoma","volume":"10","author":"Caruso R","year":"2023","journal-title":"Eur J Case Rep Intern Med"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.014"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1801-T"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0993"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071631"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-09815-0"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2022.03.016"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03598-y"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12871"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-019-0255-4"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-021-01524-2"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.02.020"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.049"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14900"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14245"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/antib9040055"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0222-4"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01749"},{"key":"e_1_2_12_91_1","first-page":"11","article-title":"The role of neutrophil extracellular traps in cancer","volume":"12","author":"Shao BZ","year":"2021","journal-title":"Front Oncol"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00571-6"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0281-y"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01311-1"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902467R"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000473"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220011"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79431-7"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70077-z"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0707-7"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004210"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042020-042741"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.03.020"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.006"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.020"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.020"},{"key":"e_1_2_12_107_1","first-page":"12","article-title":"Acquired resistance to immune checkpoint blockades: the underlying mechanisms and potential strategies","volume":"14","author":"Zhou B","year":"2021","journal-title":"Front Immunol"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.11.002"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12301-6"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00670-4"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0805-8"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-0530-3corr1"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-021-00833-8"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.744951"},{"issue":"12","key":"e_1_2_12_115_1","article-title":"Identification of a prognostic immune signature for cervical cancer to predict survival and response to immune checkpoint inhibitors","volume":"8","author":"Yang S","year":"2019","journal-title":"Onco Targets Ther"},{"key":"e_1_2_12_116_1","article-title":"A new immune signature for survival prediction and immune checkpoint molecules in non\u2010small cell lung cancer. Front","volume":"13","author":"Han S","year":"2023","journal-title":"Oncologia"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154523"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-019-02982-4"},{"issue":"2","key":"e_1_2_12_119_1","article-title":"prognostic impact of baseline neutrophil\u2010to\u2010eosinophil ratio in patients with metastatic renal cell carcinoma treated with Nivolumab therapy in second or later lines","volume":"14","author":"Gil L","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4143"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01817-1"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14153830"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003536"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215297"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0383-1"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S153290"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-021-00334-4"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyac236"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-020-02509-1"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.11.014"},{"issue":"1","key":"e_1_2_12_131_1","first-page":"1","article-title":"Tumor\u2010infiltrating mast cells are associated with resistance to anti\u2010PD\u20101 therapy","volume":"12","author":"Somasundaram R","year":"2021","journal-title":"Nature Communications 2021 12:1"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.007"},{"key":"e_1_2_12_133_1","article-title":"Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow","author":"Lad BM","year":"2023","journal-title":"bioRxiv"},{"issue":"1","key":"e_1_2_12_134_1","first-page":"1","article-title":"Safety and anti\u2010tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor\u2010alpha: a phase I trial","volume":"14","author":"Spicer J","year":"2023","journal-title":"Nature Communications 2023"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.586757"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9595704"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.156091"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00704"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003163"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02543-z"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-023-01338-4"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11060514"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-451-7_10"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.110"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2004.23.549"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4222"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1317420"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402914"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000446"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2008.03.005"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3159"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190706"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-199711000-00004"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0321-5"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.047"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.001"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.082"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1621"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.02.016"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00490-y"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.04.029"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2379"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0001OC"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049047"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.3883"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0454OC"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.08.009"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.08.033"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.10.5909"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.04658"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.03.088"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-35723-8_2"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235998"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798357881"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101277"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI122085"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201490147"},{"issue":"2","key":"e_1_2_12_178_1","first-page":"234","article-title":"Contribution of host MMP\u20102 and MMP\u20109 to promote tumor vascularization and invasion of malignant keratinocytes","volume":"19","author":"Masson V","year":"2004","journal-title":"FASEB J"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.937565"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030536"},{"issue":"1","key":"e_1_2_12_181_1","article-title":"Identification of tumor\u2010infiltrating immune cells and prognostic validation of tumor\u2010infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real\u2010world data","volume":"9","author":"Tian X","year":"2020","journal-title":"Onco Targets Ther"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2023.152151"},{"key":"e_1_2_12_183_1","article-title":"Identification of key transcription factors and immune infiltration patterns associated with breast cancer prognosis using WGCNA and Cox regression analysis. Front","volume":"11","author":"Yin X","year":"2022","journal-title":"Oncologia"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338221106530"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203723"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.978862"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31613"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-5881"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-22-576"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/4211885"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14302"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.47162\/RJME.63.2.11"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2893336"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1770"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-3140"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061394"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-6043"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x2023e12370"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2022_221014N1020"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0962"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.13006"},{"issue":"9","key":"e_1_2_12_202_1","article-title":"Tumor stroma\u2010infiltrating mast cells predict prognosis and adjuvant chemotherapeutic benefits in patients with muscle invasive bladder cancer","volume":"7","author":"Liu Z","year":"2018","journal-title":"Onco Targets Ther"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2022.2099736"},{"issue":"1","key":"e_1_2_12_204_1","article-title":"Stromal infiltrating mast cells identify immunoevasive subtype high\u2010grade serous ovarian cancer with poor prognosis and inferior immunotherapeutic response","volume":"10","author":"Cao K","year":"2021","journal-title":"Onco Targets Ther"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2022.8300"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00584-5"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-019-00300-1"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-019-02128-5"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-23-362"},{"issue":"9","key":"e_1_2_12_210_1","first-page":"1","article-title":"Quantitative analysis of tumor\u2010associated tissue eosinophilia in recurring bladder cancer","volume":"10","author":"Popov H","year":"2018","journal-title":"Cureus"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14689"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001731"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26120"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2020.1761176"},{"issue":"5","key":"e_1_2_12_215_1","first-page":"531","article-title":"The postoperative peak number of leukocytes after hepatectomy is a significant prognostic factor for cholangiocarcinoma","volume":"10","author":"Shinke G","year":"2019","journal-title":"Mol Clin Oncol"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.09.003"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12747"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.4809"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098259"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-022-03282-6"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-018-0466-9"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2412"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.878"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.09.007"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-022-02695-y"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15220"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03359-x"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0856-x"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.02.032"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.16246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:37:52Z","timestamp":1758087472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.16246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":228,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/all.16246"],"URL":"https:\/\/doi.org\/10.1111\/all.16246","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,22]]},"assertion":[{"value":"2024-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}