{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T09:02:15Z","timestamp":1793437335307,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent chronic inflammatory condition affecting the nose and paranasal sinuses, posing a significant socio\u2010economic impact with substantial challenges in management. Biologics targeting type 2 inflammation such as dupilumab, have emerged as promising options. This study addresses a critical knowledge gap by comprehensively evaluating the 3\u2010year impact of sustained dupilumab therapy in CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicentric, retrospective collection of real\u2010world data from five tertiary referral centers in Germany was conducted, enrolling 150 adult patients. The study investigated patient\u2010reported outcomes, disease\u2010specific indices and clinical measures, focusing on therapeutic response persistence, adverse events, and factors influencing treatment continuity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results indicate significant improvements in clinical parameters from baseline (<jats:italic>n<\/jats:italic>\u2009=\u2009150) with sustained effectiveness after 36\u2009months (<jats:italic>n<\/jats:italic>\u2009=\u2009138) as indicated in mean score\u2009\u00b1\u2009standard deviation. Dupilumab treatment significantly improved overall disease\u2010related impairment (VAS score: 7.5\u2009\u00b1\u20092.5 to 1.6\u2009\u00b1\u20091.3) and rhinosinusitis symptoms (SNOT\u201022: 59.4\u2009\u00b1\u200919.4 to 18.0\u2009\u00b1\u200915.0). Nasal Polyp Scores (NPS) decreased (5.3\u2009\u00b1\u20091.8 to 0.7\u2009\u00b1\u20091.1), and olfactory function improved (3.2\u2009\u00b1\u20092.5 to 8.4\u2009\u00b1\u20092.8), with three out of four patients achieving normosmia or hyposmia after 36\u2009months. An \u201cExcellent\u201d treatment response according to EUFOREA23 criteria was observed in 76.5% of patients after 36\u2009months. Sixteen patients discontinued Dupilumab, 12 permanently. Adverse events totaled 69 in 48 patients, commonly self\u2010limiting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study highlights the enduring effectiveness and lack of habituation to dupilumab after a sustained therapy of 3\u2009years, providing valuable insights into its long\u2010term therapeutic implications for CRSwNP patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.16263","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T08:29:45Z","timestamp":1723019385000},"page":"3108-3117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Real\u2010world data show sustained therapeutic effects of dupilumab in chronic rhinosinusitis with nasal polyps (<scp>CRSwNP<\/scp>) over 3\u2009years"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6962-9999","authenticated-orcid":false,"given":"Patrick","family":"Huber","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-5610","authenticated-orcid":false,"given":"Ulrike","family":"F\u00f6rster\u2010Ruhrmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Charit\u00e9\u2010Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Olze","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Charit\u00e9\u2010Universit\u00e4tsmedizin  Berlin 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Otolaryngology, Head and Neck Surgery University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9846-7850","authenticated-orcid":false,"given":"Jan","family":"Hagemann","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Otolaryngology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Matthias","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Otolaryngology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2455-0192","authenticated-orcid":false,"given":"Ludger","family":"Klimek","sequence":"additional","affiliation":[{"name":"Center for Rhinology and Allergology  Wiesbaden 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