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Through its effects on eosinophils, IL\u20105 indirectly contributes to various pathophysiological processes including tissue damage, repair and remodelling. Understanding the importance of IL\u20105 in eosinophil\u2010associated diseases led to the development of anti\u2010IL\u20105 therapies, which provide clinical benefits across a range of conditions. However, recent evidence suggests that eosinophil\u2010depletion alone may not account for all of the therapeutic effects of anti\u2010IL\u20105 therapy and that IL\u20105 may also contribute to disease independently of its effects on eosinophils. Indeed, evidence from ex\u00a0vivo studies and targeted therapy in\u00a0vivo demonstrates that IL\u20105 and its inhibition affects a much broader range of cells beyond eosinophils, including epithelial cells, plasma cells, mast cells, basophils, neutrophils, type 2 innate lymphoid cells, T regulatory cells and fibroblasts. 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