{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:38:13Z","timestamp":1790401093815,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In Europe, Omalizumab (anti\u2010IgE) is indicated for the treatment of moderate to severe asthma, but not for IgE\u2010mediated food allergy (FA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We assessed the impact of Omalizumab on efficacy, safety, and quality of life (FA\u2010QoL) in patients with moderate to severe asthma and who have a history of anaphylaxis to peanut, tree nuts, fish, egg, milk, and\/or wheat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Food\u2010allergic children (6\u201318\u2009years) with moderate to severe asthma underwent oral food challenges (OFCs) to establish the threshold of reaction to the culprit food(s) at baseline (T0) and at 4\u2010month intervals (T1, T2, and T3) during their first year of treatment with Omalizumab. We recorded the number and severity of food\u2010allergic reactions, Asthma Control Test (ACT) scores, FA\u2010QoL, and total IgE levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 65 patients allergic to 107 foods, the No Observed Adverse Events Level (NOAEL) at T1 increased: 243\u2010 and 488\u2010fold for fresh and baked milk, respectively; 172\u2010 and 134\u2010fold for raw and baked egg; 245\u2010fold for hazelnut; 55\u2010fold for peanut; 31\u2010fold for wheat; and 10\u2010fold for fish. Full tolerance was achieved in 66.4% of OFCs at T1, 58.3% at T2, and 75% at T3. Ninety\u2010five foods were liberalized in the diet of 55 patients; the remaining 12 were introduced by 10 patients at least in traces. Throughout the study, 40 out of 65 were able to get a free diet. ACT increased from 17 (Q1\u2010Q3: 15\u201317) to 23.6 (Q1\u2010Q3: 23\u201325). The FA\u2010QoL score in children \u226412\u2009years decreased from 4.63\u2009\u00b1\u20090.74 to 2.02\u2009\u00b1\u20091.13, and in adolescents from 4.68\u2009\u00b1\u20090.92 to 1.90\u2009\u00b1\u20091.50.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>During Omalizumab therapy, a safe reintroduction of allergenic foods is feasible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration Number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , NCT06316414.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16314","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T06:23:49Z","timestamp":1726467829000},"page":"1074-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Omalizumab reduces anaphylactic reactions and allows food introduction in food\u2010allergic in children with severe asthma: An observational study"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-0568","authenticated-orcid":false,"given":"Stefania","family":"Arasi","sequence":"first","affiliation":[{"name":"Allergy Division Pediatric Hospital Bambino Gesu IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0232-3511","authenticated-orcid":false,"given":"Arianna","family":"Cafarotti","sequence":"additional","affiliation":[{"name":"Allergy Division Pediatric Hospital Bambino Gesu IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4166-2030","authenticated-orcid":false,"given":"Francesca","family":"Galletta","sequence":"additional","affiliation":[{"name":"Allergy Division Pediatric Hospital Bambino Gesu IRCCS  Rome Italy"},{"name":"Department of Human Pathology of Adult and Childhood Gaetano Barresi, Pediatric Unit University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-5045","authenticated-orcid":false,"given":"Valentina","family":"Panetta","sequence":"additional","affiliation":[{"name":"L'altrastatistica S.r.l., for GB Pharma Services &amp; 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