{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:51:02Z","timestamp":1791237062909,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010term data on the effectiveness and safety of omalizumab for chronic inducible urticaria (CIndU) in large populations are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effectiveness, safety, estimated omalizumab treatment duration and its predictors, as well as differences between CIndU subtypes, in a large long\u2010term CIndU cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multinational multicenter study was conducted at 14 specialized urticaria centres (UCAREs), including all CIndU patients ever treated with omalizumab from 2009 until July 2022. Kaplan\u2013Meier survival and regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across 234 CIndU patients (55% female; mean age 37\u2009years), 76% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009178) had standalone CIndU and 24% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956) had predominant CIndU plus minor CSU, with an observation period up to 13\u2009years. Most CIndU patients (73%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009145\/200 with available data on response) had complete\/good response to omalizumab treatment, without significant differences between CIndU subtypes. Sixty\u2010two (26%) patients discontinued omalizumab; due to well\u2010controlled disease (47%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929), ineffectiveness (34%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921), side effects (3%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), combination of ineffectiveness and side effects (3%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) and other reasons (13%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098). The median estimated omalizumab treatment duration exceeded 5\u2009years (54% drug survival at 5\u2009years) and was mostly determined by well\u2010controlled disease. Higher age predicted a lower chance to discontinue omalizumab due to well\u2010controlled disease (HR 0.969, 95%CI 0.945\u20130.995). CIndU subtype and presence of minor CSU were not related to response and time until omalizumab discontinuation for any reason.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Omalizumab is highly effective and safe in CIndU patients, with long estimated treatment duration mainly reflecting long disease duration. Our data show omalizumab's high potential as treatment in any subtype of CIndU and support its clinical use for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16334","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:36:29Z","timestamp":1728390989000},"page":"489-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Omalizumab is effective and safe in chronic inducible urticaria (CIndU): Real\u2010world data from a large multi\u2010national UCARE study"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-2508","authenticated-orcid":false,"given":"R.","family":"Soegiharto","sequence":"first","affiliation":[{"name":"Department of Dermatology\/Allergology University Medical Centre Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-9250","authenticated-orcid":false,"given":"M.","family":"Alizadeh Aghdam","sequence":"additional","affiliation":[{"name":"Department of Dermatology\/Allergology University Medical Centre Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology and Wound Healing Centre University of Copenhagen, Bispebjerg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"van Lindonk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus MC  Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bulut Demir","sequence":"additional","affiliation":[{"name":"Department of Dermatology Marmara University School of Medicine  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mohammad Porras","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute. Universitat Pompeu Fabra de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Biomedical and Health Sciences, Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Urticaria Center of Reference and Excellence (UCARE) Institute of Allergology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Knulst","sequence":"additional","affiliation":[{"name":"Department of Dermatology\/Allergology University Medical Centre Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-481X","authenticated-orcid":false,"given":"M.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Urticaria Center of Reference and Excellence (UCARE) Institute of Allergology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Secciones Alergia Adultos y Pedi\u00e1trica Hospital Italiano de Buenos Aires Per\u00f3n  Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rudenko","sequence":"additional","affiliation":[{"name":"London Allergy and Immunology Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kocat\u00fcrk","sequence":"additional","affiliation":[{"name":"Urticaria Center of Reference and Excellence (UCARE) Institute of Allergology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Dermatology Ko\u00e7 University School of Medicine  Topkapi Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2482-3047","authenticated-orcid":false,"given":"R. 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