{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:47:25Z","timestamp":1792021645178,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eosinophilic asthma is characterized by frequent exacerbations, poor symptom control and accelerated lung function decline. It is now recognized that the immune response underlying eosinophilic asthma involves a complex network of interconnected pathways from both the adaptive and innate immune systems. Within this response, interleukin\u20105 (IL\u20105) plays a central role in eosinophil differentiation, activation and survival and has emerged as a key target for therapies treating severe asthma. The monoclonal antibodies mepolizumab and reslizumab target the ligand IL\u20105, preventing its interaction with eosinophils; in contrast, benralizumab binds to the IL\u20105 receptor (IL\u20105R), preventing IL\u20105 from binding and leading to substantially greater eosinophil reduction by enhanced antibody\u2010dependent cell\u2010mediated cytotoxicity. Although no direct head\u2010to\u2010head clinical trials of asthma have been published to formally evaluate the clinical significance of these different therapeutic approaches, the potential benefits of partial versus complete eosinophil depletion continue to remain an important area of study and debate. Here, we review the existing real\u2010world and clinical study data of anti\u2010IL\u20105\/anti\u2010IL\u20105R therapies in severe eosinophilic asthma.<\/jats:p>","DOI":"10.1111\/all.16346","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T01:43:29Z","timestamp":1728783809000},"page":"2943-2952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Targeting the\n                    <scp>IL<\/scp>\n                    \u20105 pathway in eosinophilic asthma: A comparison of anti\u2010\n                    <scp>IL<\/scp>\n                    \u20105 versus anti\u2010\n                    <scp>IL<\/scp>\n                    \u20105 receptor agents"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2299-868X","authenticated-orcid":false,"given":"David J.","family":"Jackson","sequence":"first","affiliation":[{"name":"Guy's Severe Asthma Centre Guy's and St Thomas' NHS Trust  London UK"},{"name":"School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Wechsler","sequence":"additional","affiliation":[{"name":"Department of Medicine National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Brusselle","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Buhl","sequence":"additional","affiliation":[{"name":"Pulmonary Department Mainz University Hospital  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)33311-1"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2016.03.006"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.04.013"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00024-2015"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00100-2015"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-018-0192-5"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201406-1039OC"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009124"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.865973"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1783242"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.03.023"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0823"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3786"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14620"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.03.025"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14221"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034975"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040834"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.S150656"},{"key":"e_1_2_15_21_1","unstructured":"Teva Pharmaceuticals Ltd.Cinqaero (reslizumab) summary of product characteristics 27 July 2023.2023Updated July 2023.https:\/\/www.medicines.org.uk\/emc\/product\/4370\/smpc\/print#DOCREVISION. [Accessed 27 July 2023]"},{"key":"e_1_2_15_22_1","unstructured":"GlaxoSmithKline.Nucala (mepolizumab) Prescribing information.2023https:\/\/gskpro.com\/content\/dam\/global\/hcpportal\/en_US\/Prescribing_Information\/Nucala\/pdf\/NUCALA\u2010PI\u2010PIL\u2010IFU\u2010COMBINED.PDF. [Accessed August 2023]"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15056"},{"key":"e_1_2_15_24_1","unstructured":"GlaxoSmithKline.Nucala (mepolizumab) Summary of product characteristics.2022https:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/nucala\u2010epar\u2010product\u2010information_en.pdf. [Accessed August 2023]"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15434"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(12)60988-x"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403290"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.08.037"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201103-0396OC"},{"key":"e_1_2_15_30_1","unstructured":"AstraZeneca Pharmaceuticals LP.FASENRA\u00ae (benralizumab) [package insert].2023Updated February 2021.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2019\/761070s005lbl.pdf. [Accessed 5 May 2023]"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2311155"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14902"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)31324-1"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)31322-8"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003-0729LE"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202308-1413LE"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/jaa.S319572"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00042-9"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.07.058"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2024.107611"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.12.045"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(21)00004-7"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.02.014"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01521-2023"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00703-2018"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.09.036"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403291"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.06.050"},{"key":"e_1_2_15_49_1","doi-asserted-by":"crossref","unstructured":"HowellI YangF BrownV et\u00a0al.Anti\u2010inflammatory effects of oral prednisolone at stable state in people treated with mepolizumab: a proteomic and bulk transcriptomics analysis.medRxiv.2024. doi:10.1101\/2024.02.14.24302812","DOI":"10.1101\/2024.02.14.24302812"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703501"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00352-0"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.07.014"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02259-2019"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14737"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02284-5"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01785-2017"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02536-2017"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.09.033"},{"key":"e_1_2_15_59_1","article-title":"Towards clinical remission in severe asthma: an analysis of patients treated with benralizumab in the phase 3b ANDHI trial","volume":"205","author":"Harrison T","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(20)30414-8"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(18)30406-5"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2023.23034"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2021.1941065"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02098-1"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01767-z"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01217-2022"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1150162"}],"updated-by":[{"DOI":"10.1111\/all.16541","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000}}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.16346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T09:09:06Z","timestamp":1737968946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.16346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,12]]},"references-count":66,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/all.16346"],"URL":"https:\/\/doi.org\/10.1111\/all.16346","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,12]]},"assertion":[{"value":"2024-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}