{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:58:59Z","timestamp":1791295139997,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic rhinitis and\/or conjunctivitis (AR\/C) induced by tree pollen is common and negatively impacts quality of life in children and adolescents. This phase III trial investigated the efficacy and safety of the SQ tree SLIT\u2010tablet in a paediatric population (5\u201317\u2009years) with moderate\u2010to\u2010severe AR\/C induced by pollen from birch and trees in the birch homologous group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine hundred and fifty\u2010two subjects were randomized (1:1) to daily treatment with SQ tree SLIT\u2010tablet or placebo for up to 52\u2009weeks and had free access to AR\/C symptom\u2010relieving medications. The primary endpoint was the average total combined score (TCS); sum of average daily symptom score (DSS) and average daily medication score (DMS) during the birch pollen season (BPS). Key secondary endpoints included average DSS and DMS during BPS and average TCS, DSS and DMS during tree pollen season (TPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SQ tree SLIT\u2010tablet demonstrated a statistically significant and clinically relevant treatment effect compared with placebo for the TCS during BPS with an absolute treatment difference of 1.29 (95% CI: 0.58, 2.00;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0004) and a relative reduction of 21.9% (95% CI: 10.6, 31.9). Results were substantiated by reductions in both DSS and DMS versus placebo during the BPS and in DSS, DMS and TCS during the TPS. Treatment was generally well tolerated. Most treatment\u2010related adverse events were mild or moderate local administration site reactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first paediatric trial to provide robust evidence of efficacy and safety of the SQ tree SLIT\u2010tablet in tree pollen\u2010induced AR\/C in a paediatric population (5\u201317\u2009years).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16363","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T09:40:23Z","timestamp":1730713223000},"page":"795-806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The\n                    <scp>SQ<\/scp>\n                    tree sublingual immunotherapy tablet is effective and well tolerated in children\u2014A pivotal phase\n                    <scp>III<\/scp>\n                    trial"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8001-1165","authenticated-orcid":false,"given":"Monika","family":"Gappa","sequence":"first","affiliation":[{"name":"Center for Paediatric and Adolescent Medicine Evangelic Hospital D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Clinique sp\u00e9cialis\u00e9e en allergie de la capitale  Qu\u00e9bec City Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6620-9224","authenticated-orcid":false,"given":"Fritz","family":"Horak","sequence":"additional","affiliation":[{"name":"Allergiezentrum Wien West  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-5976","authenticated-orcid":false,"given":"Ewa","family":"Cichocka\u2010Jarosz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrie","family":"Dalgaard","sequence":"additional","affiliation":[{"name":"ALK\u2010Abell\u00f3  H\u00f8rsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Hargreaves","sequence":"additional","affiliation":[{"name":"ALK\u2010Abell\u00f3  H\u00f8rsholm Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Mikler","sequence":"additional","affiliation":[{"name":"Pediatric clinic, University hospital in Martin and Jessenius medical faculty in Martin, Commenius University  Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Emeryk","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Disease and Children Rheumatology Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten Skamstrup","family":"Hansen","sequence":"additional","affiliation":[{"name":"Allergy Clinic &amp; 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