{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:39:43Z","timestamp":1791214783904,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subcutaneous immunotherapy has emerged as an effective option for treating allergic diseases. Here, we assessed the clinical impact of the mannan\u2010conjugated birch pollen polymerized allergoid T502 in birch pollen\u2010induced allergic rhinoconjunctivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, randomized, double\u2010blind placebo\u2010controlled phase III trial, 298 birch pollen\u2013allergic adult patients were treated across 28 trial sites in Germany. Patients received either placebo or 23,000 mTU T502 subcutaneously over five pre\u2010seasonal visits. Efficacy was assessed by comparing the combined symptom and medication score (CSMS) between placebo and T502 during the peak birch pollen season 2022. Safety, tolerability and immunologic effects were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the peak birch pollen season, the median CSMS of the T502 group was reduced by 33% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) compared to placebo. The median daily symptom score and daily medication score were reduced by 30.4% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 56.3% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045), respectively. Health related quality of life improved as reflected by reduction of RQLQ values by 31.5% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Production of\n                      <jats:italic>Bet v 1<\/jats:italic>\n                      sIgG4 and\n                      <jats:italic>Bet v 1<\/jats:italic>\n                      sIgG increased up to 6.2\u2010fold and 3\u2010fold respectively in the T502 group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The sIgE\/sIgG4 ratio was strongly reduced in the T502 group at V7 (\u221262.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                    <jats:p>No fatalities nor serious adverse events were reported. In total, 16 systemic allergic reactions occurred (Grade I\/II).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with T502 significantly reduced symptoms and medication need in rhinoconjunctivitis patients. The treatment is well tolerated and safe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16387","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T04:33:36Z","timestamp":1731126816000},"page":"817-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Short\u2010course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-810X","authenticated-orcid":false,"given":"Ralph","family":"M\u00f6sges","sequence":"first","affiliation":[{"name":"ClinCompetence Cologne GmbH Theodor\u2010Heuss\u2010Ring 14  Cologne Germany"},{"name":"Institute of Medical Statistics and Computational Biology, Faculty of Medicine University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6461-8593","authenticated-orcid":false,"given":"Esther","family":"Raskopf","sequence":"additional","affiliation":[{"name":"ClinCompetence Cologne GmbH Theodor\u2010Heuss\u2010Ring 14  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2455-0192","authenticated-orcid":false,"given":"Ludger","family":"Klimek","sequence":"additional","affiliation":[{"name":"Center for Rhinology and Allergology  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-9639","authenticated-orcid":false,"given":"Oliver","family":"Pfaar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy University Hospital Marburg, Philipps\u2010Universit\u00e4t Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1204-0627","authenticated-orcid":false,"given":"Stefan","family":"Zielen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital, Goethe University Frankfurt  Frankfurt Germany"},{"name":"Respiratory Research Institute Medaimun GmbH  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5422-0220","authenticated-orcid":false,"given":"Elena","family":"Xenofontos","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology, Faculty of Medicine University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0646-8091","authenticated-orcid":false,"given":"Lea","family":"Decker","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology, Faculty of Medicine University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9323-6887","authenticated-orcid":false,"given":"Christian","family":"Neuhof","sequence":"additional","affiliation":[{"name":"ClinCompetence Cologne GmbH Theodor\u2010Heuss\u2010Ring 14  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-5412","authenticated-orcid":false,"given":"Anna","family":"Rybachuk","sequence":"additional","affiliation":[{"name":"ClinCompetence Cologne GmbH Theodor\u2010Heuss\u2010Ring 14  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-4305","authenticated-orcid":false,"given":"Cengizhan","family":"Acikel","sequence":"additional","affiliation":[{"name":"ClinCompetence Cologne GmbH Theodor\u2010Heuss\u2010Ring 14  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-2013","authenticated-orcid":false,"given":"Hacer","family":"Sahin","sequence":"additional","affiliation":[{"name":"ClinCompetence Cologne GmbH Theodor\u2010Heuss\u2010Ring 14  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0222-5954","authenticated-orcid":false,"given":"Silke","family":"Allekotte","sequence":"additional","affiliation":[{"name":"ClinCompetence Cologne GmbH Theodor\u2010Heuss\u2010Ring 14  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-4105","authenticated-orcid":false,"given":"Sandra","family":"del Pozo Collado","sequence":"additional","affiliation":[{"name":"Inmunotek S.L. 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