{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:45:24Z","timestamp":1792449924440,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with severe asthma, treatment with anti\u2010interleukin\u20105 (IL\u20105) biologics can lead to a reduction in fractional exhaled nitric oxide (FeNO) in some patients. The clinical implications of varying FeNO responses to anti\u2010IL\u20105 biologics remain unclear. This study aims to categorise patients based on their FeNO response to anti\u2010IL\u20105 biologics and evaluate the association of these categories with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the Danish Severe Asthma Register (DSAR) to identify the early FeNO response profiles in patients receiving anti\u2010IL5 biologics. We defined FeNO responders as patients with elevated FeNO levels at baseline and a decrease corresponding to the minimal clinically important difference (MCID) at 4\u2009months of follow\u2010up and FeNO non\u2010responders as those who did not experience a decrease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 403 patients on anti\u2010IL5 treatment in DSAR, and 265 (66%) had elevated FeNO levels at baseline. After 4\u2009months of treatment, 151 (57%) patients showed a significant decrease in FeNO levels, and 114 (43%) did not. FeNO responders were more likely to achieve clinical remission of asthma (34% vs. 19%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01, OR 2.11, CI 1.04, 5.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) than FeNO non\u2010responders after 12\u2009months of treatment. The higher remission rates in FeNO responders mainly reflected a higher rate of normalisation of lung function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FeNO levels were reduced after anti\u2010IL5 treatment in a significant proportion of patients treated with anti\u2010IL5, and this was associated with clinical remission. Early FeNO response to anti\u2010IL5 could potentially be used as a biomarker to guide management decisions with biologics towards remission of disease in severe asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16425","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T05:37:53Z","timestamp":1734154673000},"page":"986-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Early Reduction of\n                    <scp>FeNO<\/scp>\n                    on Anti\u2010\n                    <scp>IL5<\/scp>\n                    Biologics Is Associated With Clinical Remission of Severe Asthma"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4954-0863","authenticated-orcid":false,"given":"Marianne Baastrup","family":"Soendergaard","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Copenhagen University Hospital\u2013Bispebjerg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Copenhagen University Hospital\u2013Bispebjerg  Copenhagen Denmark"},{"name":"Centre for Clinical Research and Prevention Frederiksberg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-0740","authenticated-orcid":false,"given":"Kjell Erik Julius","family":"H\u00e5kansson","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Copenhagen University Hospital\u2013Bispebjerg  Copenhagen Denmark"},{"name":"Department of Respiratory Medicine Copenhagen University Hospital\u2013Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"von B\u00fclow","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Copenhagen University Hospital\u2013Bispebjerg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sofie","family":"Bjerrum","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases and Allergy Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes Martin","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases and Allergy Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie Lock","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Makowska","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Allergy Clinic Gentofte University Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Rikard","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Allergy Clinic Gentofte University Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Bonnesen","family":"Bertelsen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Gentofte University Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Steen","family":"Krogh","sequence":"additional","affiliation":[{"name":"Zitelab ApS  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Hilberg","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sygehus Lillebaelt\u2013Vejle Sygehus  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Suppli","family":"Ulrik","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Copenhagen University Hospital\u2013Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4825-9436","authenticated-orcid":false,"given":"Celeste","family":"Porsbjerg","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Copenhagen University Hospital\u2013Bispebjerg  Copenhagen 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