{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:49:02Z","timestamp":1791776942620,"version":"4.3.4"},"reference-count":259,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019211","name":"AbbVie Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research. We specifically focus on the results of genome\u2010wide association studies in food allergy, which have identified 16 genetic variants that reach genome\u2010wide significance, many of which overlap with other allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis. Identified genes for food allergy are mainly involved in epithelial barrier function (e.g.,\n FLG<\/jats:italic>\n ,\n SERPINB7<\/jats:italic>\n ) and immune function (e.g.,\n HLA<\/jats:italic>\n ,\n IL4<\/jats:italic>\n ). Epigenome\u2010wide significant findings at 32 loci are also summarized as well as 14 additional loci with significance at a false discovery of <\u20091\u2009\u00d7\u200910\n \u22124<\/jats:sup>\n . Integration of epigenetic and genetic data is discussed in the context of disease mechanisms, many of which are shared with other allergic diseases. The potential utility of genetic and epigenetic discoveries is deliberated. In the future, genetic and epigenetic markers may offer ways to predict the presence or absence of clinical IgE\u2010mediated food allergy among sensitized individuals, likelihood of development of natural tolerance, and response to immunotherapy.\n <\/jats:p>","DOI":"10.1111\/all.16429","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T05:18:52Z","timestamp":1734585532000},"page":"106-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Food Allergy Genetics and Epigenetics: A Review of Genome\u2010Wide Association Studies"],"prefix":"10.1111","volume":"80","author":[{"given":"Aleix","family":"Arnau\u2010Soler","sequence":"first","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) Berlin Germany"},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Zu Berlin Berlin Germany"},{"name":"Experimental and Clinical Research Center, a Joint Cooperation of Max Delbruck Center for Molecular Medicine and Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ) Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte L.","family":"Tremblay","sequence":"additional","affiliation":[{"name":"D\u00e9partement Des Sciences Fondamentales Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi Saguenay Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2757-5210","authenticated-orcid":false,"given":"Yidan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Pediatric Allergology University Medical Center Groningen, Beatrix Children's Hospital, University of Groningen Groningen the Netherlands"},{"name":"University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC) Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Madore","sequence":"additional","affiliation":[{"name":"D\u00e9partement Des Sciences Fondamentales Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi Saguenay Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Simard","sequence":"additional","affiliation":[{"name":"D\u00e9partement Des Sciences Fondamentales Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi Saguenay Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin T. 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